Commensal flora and the regulation of inflammatory and autoimmune responses

Research output: Contribution to journalReview articlepeer-review

Authors

Colleges, School and Institutes

External organisations

  • Garvan Institute of Medical Research
  • Cooperative Research Center for Asthma and Airways
  • University of New South Wales
  • Monash University

Abstract

The gut microbiota has recently been recognized for its role in immune regulation, and changes in gut microbiota may be the basis for an increased incidence of autoimmune diseases and asthma in developed countries. Beneficial microbes produce factors that are distributed systemically, and therefore can influence peripheral inflammatory responses. Such symbiosis factors are important for the control and resolution of inflammation and autoimmune diseases. Here we discuss immune regulation by recently identified symbiosis factors and how certain environmental factors favor their production and influence the composition of the gut microflora.

Details

Original languageEnglish
Pages (from-to)139-145
Number of pages7
JournalSeminars in Immunology
Volume23
Issue number2
Publication statusPublished - Apr 2011

Keywords

  • Autoimmunity, Commensals, Dysbiosis, Gut bacteria, Microbiota, Symbiosis factors

ASJC Scopus subject areas