Colorectal cancer in patients with inflammatory bowel disease after liver transplantation for primary sclerosing cholangitis

Research output: Contribution to journalArticle

Authors

  • Alonso Vera
  • BK Gunson
  • V Ussatoff
  • Anthony Mayer
  • J Buckles
  • Paul McMaster
  • James Neuberger
  • Darius Mirza

Abstract

BACKGROUND: Patients with primary sclerosing cholangitis (PSC) and inflammatory bowel disease (IBD) may have an increased risk of developing colorectal cancer (CRC) after liver transplantation (LT). We evaluated our patients with PSC after LT to identify risk factors for CRC and its impact on survival. PATIENTS AND METHODS: A total of 152 patients (108 men, 100 with IBD) with PSC who underwent 173 LTs between 1986 and May 2000 were analyzed in three groups: (1) PSC without IBD (n=52); (2) PSC with colectomy (pre-LT and at LT) (n=17, colectomy pre-LT in 13 and simultaneous colectomy at LT in four); and (3) PSC with IBD and an intact colon (n=83). The following factors were studied: age, gender, liver, and renal biochemistry, international normalized ratio, Child-Pugh stage, operative time, blood use, hospital stay, immunosuppression, risk of CRC, retransplantation rate, and mortality. RESULTS: The incidence of CRC after LT was 5.3% (8/152) compared with 0.6% (7/1,184) in non-PSC cases (P

Details

Original languageEnglish
Pages (from-to)1983-1988
Number of pages6
JournalTransplantation
Volume75
Issue number12
Publication statusPublished - 1 Jun 2003

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