TY - JOUR
T1 - Collateralization and the response to obstruction of epicardial coronary arteries
AU - Tayebjee, Muzahir
AU - Lip, Gregory
AU - Macfadyen, Robert
PY - 2004/5/1
Y1 - 2004/5/1
N2 - Occlusive coronary disease is an important cause of global morbidity and mortality. While mechanical revascularization is effective, some individuals are not amenable to such interventions, and have a poorer prognosis. However, collateral circulation can protect and preserve myocardium around the time of coronary occlusion, contribute to better residual myocardial contractility, and lessen symptoms. We describe the anatomy and physiology of coronary collateralization, its component parts (angiogenesis and arteriogenesis), the current methods for definition of the collateral response and how this might be manipulated. The manipulation of this process is a realistic possibility for future adjuvant treatment of coronary artery disease.
AB - Occlusive coronary disease is an important cause of global morbidity and mortality. While mechanical revascularization is effective, some individuals are not amenable to such interventions, and have a poorer prognosis. However, collateral circulation can protect and preserve myocardium around the time of coronary occlusion, contribute to better residual myocardial contractility, and lessen symptoms. We describe the anatomy and physiology of coronary collateralization, its component parts (angiogenesis and arteriogenesis), the current methods for definition of the collateral response and how this might be manipulated. The manipulation of this process is a realistic possibility for future adjuvant treatment of coronary artery disease.
U2 - 10.1093/qjmed/hch053
DO - 10.1093/qjmed/hch053
M3 - Article
C2 - 15100419
SN - 1460-2393
VL - 97
SP - 259
EP - 272
JO - QJM
JF - QJM
IS - 5
ER -