Cognitive, motor, behavioural and academic performances of children born preterm: a meta-analysis and systematic review involving 64 061 children

Research output: Contribution to journalArticlepeer-review

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Cognitive, motor, behavioural and academic performances of children born preterm : a meta-analysis and systematic review involving 64 061 children. / Allotey, J; Zamora, J; Cheong-See, F; Kalidindi, M; Arroyo-Manzano, D; Asztalos, E; van der Post, Jam; Mol, B W; Moore, D; Birtles, D; Khan, K S; Thangaratinam, S.

In: BJOG: An International Journal of Obstetrics & Gynaecology, Vol. 125, No. 1, 01.2018, p. 16-25.

Research output: Contribution to journalArticlepeer-review

Harvard

Allotey, J, Zamora, J, Cheong-See, F, Kalidindi, M, Arroyo-Manzano, D, Asztalos, E, van der Post, J, Mol, BW, Moore, D, Birtles, D, Khan, KS & Thangaratinam, S 2018, 'Cognitive, motor, behavioural and academic performances of children born preterm: a meta-analysis and systematic review involving 64 061 children', BJOG: An International Journal of Obstetrics & Gynaecology, vol. 125, no. 1, pp. 16-25. https://doi.org/10.1111/1471-0528.14832

APA

Allotey, J., Zamora, J., Cheong-See, F., Kalidindi, M., Arroyo-Manzano, D., Asztalos, E., van der Post, J., Mol, B. W., Moore, D., Birtles, D., Khan, K. S., & Thangaratinam, S. (2018). Cognitive, motor, behavioural and academic performances of children born preterm: a meta-analysis and systematic review involving 64 061 children. BJOG: An International Journal of Obstetrics & Gynaecology, 125(1), 16-25. https://doi.org/10.1111/1471-0528.14832

Vancouver

Author

Allotey, J ; Zamora, J ; Cheong-See, F ; Kalidindi, M ; Arroyo-Manzano, D ; Asztalos, E ; van der Post, Jam ; Mol, B W ; Moore, D ; Birtles, D ; Khan, K S ; Thangaratinam, S. / Cognitive, motor, behavioural and academic performances of children born preterm : a meta-analysis and systematic review involving 64 061 children. In: BJOG: An International Journal of Obstetrics & Gynaecology. 2018 ; Vol. 125, No. 1. pp. 16-25.

Bibtex

@article{d7fbfbe0e5a04edf913274c50c7a1d8a,
title = "Cognitive, motor, behavioural and academic performances of children born preterm: a meta-analysis and systematic review involving 64 061 children",
abstract = "BACKGROUND: Preterm birth may leave the brain vulnerable to dysfunction. Knowledge of future neurodevelopmental delay in children born with various degrees of prematurity is needed to inform practice and policy.OBJECTIVE: To quantify the long-term cognitive, motor, behavioural and academic performance of children born with different degrees of prematurity compared with term-born children.SEARCH STRATEGY: PubMed and Embase were searched from January 1980 to December 2016 without language restrictions.SELECTION CRITERIA: Observational studies that reported neurodevelopmental outcomes from 2 years of age in children born preterm compared with a term-born cohort.DATA COLLECTION AND ANALYSIS: We pooled individual estimates of standardised mean differences (SMD) and odds ratios (OR) with 95% confidence intervals using a random effects model.MAIN RESULTS: We included 74 studies (64 061 children). Preterm children had lower cognitive scores for FSIQ (SMD: -0.70; 95% CI: -0.73 to -0.66), PIQ (SMD: -0.67; 95% CI: -0.73 to -0.60) and VIQ (SMD: -0.53; 95% CI: -0.60 to -0.47). Lower scores for preterm children in motor skills, behaviour, reading, mathematics and spelling were observed at primary school age, and this persisted to secondary school age, except for mathematics. Gestational age at birth accounted for 38-48% of the observed IQ variance. ADHD was diagnosed twice as often in preterm children (OR: 1.6; 95% CI: 1.3-1.8), with a differential effect observed according to the severity of prematurity (I2 = 49.4%, P = 0.03).CONCLUSIONS: Prematurity of any degree affects the cognitive performance of children born preterm. The poor neurodevelopment persists at various ages of follow up. Parents, educators, healthcare professionals and policy makers need to take into account the additional academic, emotional and behavioural needs of these children.TWEETABLE ABSTRACT: Adverse effect of preterm birth on a child's neurodevelopment persists up to adulthood.",
keywords = "Academic Success, Child, Child Behavior Disorders/etiology, Child, Preschool, Cognition Disorders/etiology, Developmental Disabilities/etiology, Gestational Age, Humans, Infant, Infant, Newborn, Infant, Premature/physiology, Motor Skills Disorders/etiology, Observational Studies as Topic, Psychomotor Disorders/etiology",
author = "J Allotey and J Zamora and F Cheong-See and M Kalidindi and D Arroyo-Manzano and E Asztalos and {van der Post}, Jam and Mol, {B W} and D Moore and D Birtles and Khan, {K S} and S Thangaratinam",
note = "{\textcopyright} 2017 Royal College of Obstetricians and Gynaecologists.",
year = "2018",
month = jan,
doi = "10.1111/1471-0528.14832",
language = "English",
volume = "125",
pages = "16--25",
journal = "BJOG: An International Journal of Obstetrics & Gynaecology",
issn = "1470-0328",
publisher = "Wiley",
number = "1",

}

RIS

TY - JOUR

T1 - Cognitive, motor, behavioural and academic performances of children born preterm

T2 - a meta-analysis and systematic review involving 64 061 children

AU - Allotey, J

AU - Zamora, J

AU - Cheong-See, F

AU - Kalidindi, M

AU - Arroyo-Manzano, D

AU - Asztalos, E

AU - van der Post, Jam

AU - Mol, B W

AU - Moore, D

AU - Birtles, D

AU - Khan, K S

AU - Thangaratinam, S

N1 - © 2017 Royal College of Obstetricians and Gynaecologists.

PY - 2018/1

Y1 - 2018/1

N2 - BACKGROUND: Preterm birth may leave the brain vulnerable to dysfunction. Knowledge of future neurodevelopmental delay in children born with various degrees of prematurity is needed to inform practice and policy.OBJECTIVE: To quantify the long-term cognitive, motor, behavioural and academic performance of children born with different degrees of prematurity compared with term-born children.SEARCH STRATEGY: PubMed and Embase were searched from January 1980 to December 2016 without language restrictions.SELECTION CRITERIA: Observational studies that reported neurodevelopmental outcomes from 2 years of age in children born preterm compared with a term-born cohort.DATA COLLECTION AND ANALYSIS: We pooled individual estimates of standardised mean differences (SMD) and odds ratios (OR) with 95% confidence intervals using a random effects model.MAIN RESULTS: We included 74 studies (64 061 children). Preterm children had lower cognitive scores for FSIQ (SMD: -0.70; 95% CI: -0.73 to -0.66), PIQ (SMD: -0.67; 95% CI: -0.73 to -0.60) and VIQ (SMD: -0.53; 95% CI: -0.60 to -0.47). Lower scores for preterm children in motor skills, behaviour, reading, mathematics and spelling were observed at primary school age, and this persisted to secondary school age, except for mathematics. Gestational age at birth accounted for 38-48% of the observed IQ variance. ADHD was diagnosed twice as often in preterm children (OR: 1.6; 95% CI: 1.3-1.8), with a differential effect observed according to the severity of prematurity (I2 = 49.4%, P = 0.03).CONCLUSIONS: Prematurity of any degree affects the cognitive performance of children born preterm. The poor neurodevelopment persists at various ages of follow up. Parents, educators, healthcare professionals and policy makers need to take into account the additional academic, emotional and behavioural needs of these children.TWEETABLE ABSTRACT: Adverse effect of preterm birth on a child's neurodevelopment persists up to adulthood.

AB - BACKGROUND: Preterm birth may leave the brain vulnerable to dysfunction. Knowledge of future neurodevelopmental delay in children born with various degrees of prematurity is needed to inform practice and policy.OBJECTIVE: To quantify the long-term cognitive, motor, behavioural and academic performance of children born with different degrees of prematurity compared with term-born children.SEARCH STRATEGY: PubMed and Embase were searched from January 1980 to December 2016 without language restrictions.SELECTION CRITERIA: Observational studies that reported neurodevelopmental outcomes from 2 years of age in children born preterm compared with a term-born cohort.DATA COLLECTION AND ANALYSIS: We pooled individual estimates of standardised mean differences (SMD) and odds ratios (OR) with 95% confidence intervals using a random effects model.MAIN RESULTS: We included 74 studies (64 061 children). Preterm children had lower cognitive scores for FSIQ (SMD: -0.70; 95% CI: -0.73 to -0.66), PIQ (SMD: -0.67; 95% CI: -0.73 to -0.60) and VIQ (SMD: -0.53; 95% CI: -0.60 to -0.47). Lower scores for preterm children in motor skills, behaviour, reading, mathematics and spelling were observed at primary school age, and this persisted to secondary school age, except for mathematics. Gestational age at birth accounted for 38-48% of the observed IQ variance. ADHD was diagnosed twice as often in preterm children (OR: 1.6; 95% CI: 1.3-1.8), with a differential effect observed according to the severity of prematurity (I2 = 49.4%, P = 0.03).CONCLUSIONS: Prematurity of any degree affects the cognitive performance of children born preterm. The poor neurodevelopment persists at various ages of follow up. Parents, educators, healthcare professionals and policy makers need to take into account the additional academic, emotional and behavioural needs of these children.TWEETABLE ABSTRACT: Adverse effect of preterm birth on a child's neurodevelopment persists up to adulthood.

KW - Academic Success

KW - Child

KW - Child Behavior Disorders/etiology

KW - Child, Preschool

KW - Cognition Disorders/etiology

KW - Developmental Disabilities/etiology

KW - Gestational Age

KW - Humans

KW - Infant

KW - Infant, Newborn

KW - Infant, Premature/physiology

KW - Motor Skills Disorders/etiology

KW - Observational Studies as Topic

KW - Psychomotor Disorders/etiology

U2 - 10.1111/1471-0528.14832

DO - 10.1111/1471-0528.14832

M3 - Article

C2 - 29024294

VL - 125

SP - 16

EP - 25

JO - BJOG: An International Journal of Obstetrics & Gynaecology

JF - BJOG: An International Journal of Obstetrics & Gynaecology

SN - 1470-0328

IS - 1

ER -