Coetaneous catalytic kinetic resolution of alkynes and azides through asymmetric triazole formation
Research output: Contribution to journal › Article › peer-review
Authors
Colleges, School and Institutes
Abstract
A non-enzymatic simultaneous (coined coetaneous) kinetic resolution of a racemic alkyne and racemic azide, utilising an asymmetric CuAAC reaction is reported. The use of a CuCl (R,R)-Ph-Pybox catalyst system effects a simultaneous kinetic resolution of two racemic starting materials to give one major triazolic diastereoisomer in the ratio 74:12:4:10 (dr 84:16, 90% ee maj). The corresponding control reaction using an achiral copper catalyst gives the four possible diastereoisomers in a 23:27:23:27 ratio, demonstrating minimal inherent substrate control.
Details
Original language | English |
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Article number | 15086 |
Journal | Scientific Reports |
Volume | 9 |
Issue number | 1 |
Publication status | Published - 21 Oct 2019 |