c-Myb Is Required for Neural Progenitor Cell Proliferation and Maintenance of the Neural Stem Cell Niche in Adult Brain

Research output: Contribution to journalArticle

Standard

c-Myb Is Required for Neural Progenitor Cell Proliferation and Maintenance of the Neural Stem Cell Niche in Adult Brain. / Malaterre, J; Mantamadiotis, T; Dworkin, S; Lightowler, S; Yang, Q; Ransome, MI; Turnley, AM; Nichols, NR; Emambokus, NR; Frampton, Jonathan; Ramsay, RG.

In: Stem Cells, Vol. 26, No. 1, 29.11.2007, p. 173-81.

Research output: Contribution to journalArticle

Harvard

Malaterre, J, Mantamadiotis, T, Dworkin, S, Lightowler, S, Yang, Q, Ransome, MI, Turnley, AM, Nichols, NR, Emambokus, NR, Frampton, J & Ramsay, RG 2007, 'c-Myb Is Required for Neural Progenitor Cell Proliferation and Maintenance of the Neural Stem Cell Niche in Adult Brain', Stem Cells, vol. 26, no. 1, pp. 173-81. https://doi.org/10.1634/stemcells.2007-0293

APA

Malaterre, J., Mantamadiotis, T., Dworkin, S., Lightowler, S., Yang, Q., Ransome, MI., Turnley, AM., Nichols, NR., Emambokus, NR., Frampton, J., & Ramsay, RG. (2007). c-Myb Is Required for Neural Progenitor Cell Proliferation and Maintenance of the Neural Stem Cell Niche in Adult Brain. Stem Cells, 26(1), 173-81. https://doi.org/10.1634/stemcells.2007-0293

Vancouver

Author

Malaterre, J ; Mantamadiotis, T ; Dworkin, S ; Lightowler, S ; Yang, Q ; Ransome, MI ; Turnley, AM ; Nichols, NR ; Emambokus, NR ; Frampton, Jonathan ; Ramsay, RG. / c-Myb Is Required for Neural Progenitor Cell Proliferation and Maintenance of the Neural Stem Cell Niche in Adult Brain. In: Stem Cells. 2007 ; Vol. 26, No. 1. pp. 173-81.

Bibtex

@article{d1d5222b394c421a9b7dc725d12328e8,
title = "c-Myb Is Required for Neural Progenitor Cell Proliferation and Maintenance of the Neural Stem Cell Niche in Adult Brain",
abstract = "Ongoing production of neurons in adult brain is restricted to specialized neurogenic niches. Deregulated expression of genes controlling homeostasis of neural progenitor cell division and/or their microenvironment underpins a spectrum of brain pathologies. Using conditional gene deletion, we show that the proto-oncogene c-myb regulates neural progenitor cell proliferation and maintains ependymal cell integrity in mice. These two cellular compartments constitute the neurogenic niche in the adult brain. Brains devoid of c-Myb showed enlarged ventricular spaces, ependymal cell abnormalities, and reduced neurogenesis. Neural progenitor cells lacking c-Myb showed a reduced intrinsic proliferative capacity and reduction of Sox-2 and Pax-6 expression. These data point to an important role for c-Myb in the neurogenic niche of the adult brain.",
keywords = "mice, ependymal cells, transcription factor, neural stem cells, c-Myb",
author = "J Malaterre and T Mantamadiotis and S Dworkin and S Lightowler and Q Yang and MI Ransome and AM Turnley and NR Nichols and NR Emambokus and Jonathan Frampton and RG Ramsay",
year = "2007",
month = nov,
day = "29",
doi = "10.1634/stemcells.2007-0293",
language = "English",
volume = "26",
pages = "173--81",
journal = "Stem Cells",
issn = "1066-5099",
publisher = "AlphaMed Press",
number = "1",

}

RIS

TY - JOUR

T1 - c-Myb Is Required for Neural Progenitor Cell Proliferation and Maintenance of the Neural Stem Cell Niche in Adult Brain

AU - Malaterre, J

AU - Mantamadiotis, T

AU - Dworkin, S

AU - Lightowler, S

AU - Yang, Q

AU - Ransome, MI

AU - Turnley, AM

AU - Nichols, NR

AU - Emambokus, NR

AU - Frampton, Jonathan

AU - Ramsay, RG

PY - 2007/11/29

Y1 - 2007/11/29

N2 - Ongoing production of neurons in adult brain is restricted to specialized neurogenic niches. Deregulated expression of genes controlling homeostasis of neural progenitor cell division and/or their microenvironment underpins a spectrum of brain pathologies. Using conditional gene deletion, we show that the proto-oncogene c-myb regulates neural progenitor cell proliferation and maintains ependymal cell integrity in mice. These two cellular compartments constitute the neurogenic niche in the adult brain. Brains devoid of c-Myb showed enlarged ventricular spaces, ependymal cell abnormalities, and reduced neurogenesis. Neural progenitor cells lacking c-Myb showed a reduced intrinsic proliferative capacity and reduction of Sox-2 and Pax-6 expression. These data point to an important role for c-Myb in the neurogenic niche of the adult brain.

AB - Ongoing production of neurons in adult brain is restricted to specialized neurogenic niches. Deregulated expression of genes controlling homeostasis of neural progenitor cell division and/or their microenvironment underpins a spectrum of brain pathologies. Using conditional gene deletion, we show that the proto-oncogene c-myb regulates neural progenitor cell proliferation and maintains ependymal cell integrity in mice. These two cellular compartments constitute the neurogenic niche in the adult brain. Brains devoid of c-Myb showed enlarged ventricular spaces, ependymal cell abnormalities, and reduced neurogenesis. Neural progenitor cells lacking c-Myb showed a reduced intrinsic proliferative capacity and reduction of Sox-2 and Pax-6 expression. These data point to an important role for c-Myb in the neurogenic niche of the adult brain.

KW - mice

KW - ependymal cells

KW - transcription factor

KW - neural stem cells

KW - c-Myb

U2 - 10.1634/stemcells.2007-0293

DO - 10.1634/stemcells.2007-0293

M3 - Article

C2 - 17901403

VL - 26

SP - 173

EP - 181

JO - Stem Cells

JF - Stem Cells

SN - 1066-5099

IS - 1

ER -