c-Myb Is Required for Neural Progenitor Cell Proliferation and Maintenance of the Neural Stem Cell Niche in Adult Brain

Research output: Contribution to journalArticle

Authors

  • J Malaterre
  • T Mantamadiotis
  • S Dworkin
  • S Lightowler
  • Q Yang
  • MI Ransome
  • AM Turnley
  • NR Nichols
  • NR Emambokus
  • RG Ramsay

Abstract

Ongoing production of neurons in adult brain is restricted to specialized neurogenic niches. Deregulated expression of genes controlling homeostasis of neural progenitor cell division and/or their microenvironment underpins a spectrum of brain pathologies. Using conditional gene deletion, we show that the proto-oncogene c-myb regulates neural progenitor cell proliferation and maintains ependymal cell integrity in mice. These two cellular compartments constitute the neurogenic niche in the adult brain. Brains devoid of c-Myb showed enlarged ventricular spaces, ependymal cell abnormalities, and reduced neurogenesis. Neural progenitor cells lacking c-Myb showed a reduced intrinsic proliferative capacity and reduction of Sox-2 and Pax-6 expression. These data point to an important role for c-Myb in the neurogenic niche of the adult brain.

Details

Original languageEnglish
Pages (from-to)173-81
Number of pages9
JournalStem Cells
Volume26
Issue number1
Early online date29 Nov 2007
Publication statusPublished - 29 Nov 2007

Keywords

  • mice, ependymal cells, transcription factor, neural stem cells, c-Myb