Abstract
Ongoing production of neurons in adult brain is restricted to specialized neurogenic niches. Deregulated expression of genes controlling homeostasis of neural progenitor cell division and/or their microenvironment underpins a spectrum of brain pathologies. Using conditional gene deletion, we show that the proto-oncogene c-myb regulates neural progenitor cell proliferation and maintains ependymal cell integrity in mice. These two cellular compartments constitute the neurogenic niche in the adult brain. Brains devoid of c-Myb showed enlarged ventricular spaces, ependymal cell abnormalities, and reduced neurogenesis. Neural progenitor cells lacking c-Myb showed a reduced intrinsic proliferative capacity and reduction of Sox-2 and Pax-6 expression. These data point to an important role for c-Myb in the neurogenic niche of the adult brain.
| Original language | English |
|---|---|
| Pages (from-to) | 173-81 |
| Number of pages | 9 |
| Journal | Stem Cells |
| Volume | 26 |
| Issue number | 1 |
| Early online date | 29 Nov 2007 |
| DOIs | |
| Publication status | Published - 29 Nov 2007 |
Keywords
- mice
- ependymal cells
- transcription factor
- neural stem cells
- c-Myb