CMV and Immunosenescence: from basics to clinics

Research output: Contribution to journalArticle

Authors

  • Rafael Solana
  • Raquel Tarazona
  • Allison E Aiello
  • Arne N Akbar
  • Victor Appay
  • Carmen Campos
  • Sara Cantisán
  • Luka Cicin-Sain
  • Evelyna Derhovanessian
  • Sara Ferrando-Martínez
  • Daniela Frasca
  • Tamas Fulöp
  • Sheila Govind
  • Beatrix Grubeck-Loebenstein
  • Ann Hill
  • Mikko Hurme
  • Florian Kern
  • Anis Larbi
  • Miguel López-Botet
  • Andrea B Maier
  • Janet E McElhaney
  • Elissaveta Naumova
  • Janko Nikolich-Zugich
  • Alejandra Pera
  • Natalie Riddell
  • Beatriz Sanchez-Correa
  • Paolo Sansoni
  • Rene van Lier
  • George C Wang
  • Mark R Wills
  • Maciej Zielinski
  • Graham Pawelec
  • Keith Wheatley

Abstract

ABSTRACT: Alone among herpesviruses, persistent Cytomegalovirus (CMV) markedly alters the numbers and proportions of peripheral immune cells in infected-vs-uninfected people. Because the rate of CMV infection increases with age in most countries, it has been suggested that it drives or at least exacerbates "immunosenescence". This contention remains controversial and was the primary subject of the Third International Workshop on CMV & Immunosenescence which was held in Cordoba, Spain, 15-16th March, 2012. Discussions focused on several main themes including the effects of CMV on adaptive immunity and immunosenescence, characterization of CMV-specific T cells, impact of CMV infection and ageing on innate immunity, and finally, most important, the clinical implications of immunosenescence and CMV infection. Here we summarize the major findings of this workshop.

Details

Original languageEnglish
Pages (from-to)23
JournalImmunity & Ageing
Volume9
Issue number1
Publication statusPublished - 2012