CMV and Immunosenescence: from basics to clinics

Rafael Solana; Raquel Tarazona; Allison E Aiello; Arne N Akbar; Victor Appay; Mark Beswick; Jos A Bosch; Carmen Campos; Sara Cantisán; Luka Cicin-Sain; Evelyna Derhovanessian; Sara Ferrando-Martínez; Daniela Frasca; Tamas Fulöp; Sheila Govind; Beatrix Grubeck-Loebenstein; Ann Hill; Mikko Hurme; Florian Kern; Anis Larbi; Miguel López-Botet; Andrea B Maier; Janet E McElhaney; Paul Moss; Elissaveta Naumova; Janko Nikolich-Zugich; Alejandra Pera; Jerrald L Rector; Natalie Riddell; Beatriz Sanchez-Correa; Paolo Sansoni; Delphine Sauce; Rene van Lier; George C Wang; Mark R Wills; Maciej Zielinski; Graham Pawelec; Keith Wheatley

doi:10.1186/1742-4933-9-23

CMV and Immunosenescence: from basics to clinics

Rafael Solana, Raquel Tarazona, Allison E Aiello, Arne N Akbar, Victor Appay, Mark Beswick, Jos A Bosch, Carmen Campos, Sara Cantisán, Luka Cicin-Sain, Evelyna Derhovanessian, Sara Ferrando-Martínez, Daniela Frasca, Tamas Fulöp, Sheila Govind, Beatrix Grubeck-Loebenstein, Ann Hill, Mikko Hurme, Florian Kern, Anis LarbiMiguel López-Botet, Andrea B Maier, Janet E McElhaney, Paul Moss, Elissaveta Naumova, Janko Nikolich-Zugich, Alejandra Pera, Jerrald L Rector, Natalie Riddell, Beatriz Sanchez-Correa, Paolo Sansoni, Delphine Sauce, Rene van Lier, George C Wang, Mark R Wills, Maciej Zielinski, Graham Pawelec, Keith Wheatley

Research output: Contribution to journal › Article › peer-review

106 Citations (Scopus)

Abstract

ABSTRACT: Alone among herpesviruses, persistent Cytomegalovirus (CMV) markedly alters the numbers and proportions of peripheral immune cells in infected-vs-uninfected people. Because the rate of CMV infection increases with age in most countries, it has been suggested that it drives or at least exacerbates "immunosenescence". This contention remains controversial and was the primary subject of the Third International Workshop on CMV & Immunosenescence which was held in Cordoba, Spain, 15-16th March, 2012. Discussions focused on several main themes including the effects of CMV on adaptive immunity and immunosenescence, characterization of CMV-specific T cells, impact of CMV infection and ageing on innate immunity, and finally, most important, the clinical implications of immunosenescence and CMV infection. Here we summarize the major findings of this workshop.

Original language	English
Pages (from-to)	23
Journal	Immunity & Ageing
Volume	9
Issue number	1
DOIs	https://doi.org/10.1186/1742-4933-9-23
Publication status	Published - 2012

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Solana, R., Tarazona, R., Aiello, A. E., Akbar, A. N., Appay, V., Beswick, M., Bosch, J. A., Campos, C., Cantisán, S., Cicin-Sain, L., Derhovanessian, E., Ferrando-Martínez, S., Frasca, D., Fulöp, T., Govind, S., Grubeck-Loebenstein, B., Hill, A., Hurme, M., Kern, F., ... Wheatley, K. (2012). CMV and Immunosenescence: from basics to clinics. Immunity & Ageing, 9(1), 23. https://doi.org/10.1186/1742-4933-9-23

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title = "CMV and Immunosenescence: from basics to clinics",

abstract = "ABSTRACT: Alone among herpesviruses, persistent Cytomegalovirus (CMV) markedly alters the numbers and proportions of peripheral immune cells in infected-vs-uninfected people. Because the rate of CMV infection increases with age in most countries, it has been suggested that it drives or at least exacerbates {"}immunosenescence{"}. This contention remains controversial and was the primary subject of the Third International Workshop on CMV & Immunosenescence which was held in Cordoba, Spain, 15-16th March, 2012. Discussions focused on several main themes including the effects of CMV on adaptive immunity and immunosenescence, characterization of CMV-specific T cells, impact of CMV infection and ageing on innate immunity, and finally, most important, the clinical implications of immunosenescence and CMV infection. Here we summarize the major findings of this workshop.",

author = "Rafael Solana and Raquel Tarazona and Aiello, {Allison E} and Akbar, {Arne N} and Victor Appay and Mark Beswick and Bosch, {Jos A} and Carmen Campos and Sara Cantis{\'a}n and Luka Cicin-Sain and Evelyna Derhovanessian and Sara Ferrando-Mart{\'i}nez and Daniela Frasca and Tamas Ful{\"o}p and Sheila Govind and Beatrix Grubeck-Loebenstein and Ann Hill and Mikko Hurme and Florian Kern and Anis Larbi and Miguel L{\'o}pez-Botet and Maier, {Andrea B} and McElhaney, {Janet E} and Paul Moss and Elissaveta Naumova and Janko Nikolich-Zugich and Alejandra Pera and Rector, {Jerrald L} and Natalie Riddell and Beatriz Sanchez-Correa and Paolo Sansoni and Delphine Sauce and {van Lier}, Rene and Wang, {George C} and Wills, {Mark R} and Maciej Zielinski and Graham Pawelec and Keith Wheatley",

year = "2012",

doi = "10.1186/1742-4933-9-23",

language = "English",

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Solana, R, Tarazona, R, Aiello, AE, Akbar, AN, Appay, V, Beswick, M, Bosch, JA, Campos, C, Cantisán, S, Cicin-Sain, L, Derhovanessian, E, Ferrando-Martínez, S, Frasca, D, Fulöp, T, Govind, S, Grubeck-Loebenstein, B, Hill, A, Hurme, M, Kern, F, Larbi, A, López-Botet, M, Maier, AB, McElhaney, JE, Moss, P, Naumova, E, Nikolich-Zugich, J, Pera, A, Rector, JL, Riddell, N, Sanchez-Correa, B, Sansoni, P, Sauce, D, van Lier, R, Wang, GC, Wills, MR, Zielinski, M, Pawelec, G & Wheatley, K 2012, 'CMV and Immunosenescence: from basics to clinics', Immunity & Ageing, vol. 9, no. 1, pp. 23. https://doi.org/10.1186/1742-4933-9-23

TY - JOUR

T1 - CMV and Immunosenescence

T2 - from basics to clinics

AU - Solana, Rafael

AU - Tarazona, Raquel

AU - Aiello, Allison E

AU - Akbar, Arne N

AU - Appay, Victor

AU - Beswick, Mark

AU - Bosch, Jos A

AU - Campos, Carmen

AU - Cantisán, Sara

AU - Cicin-Sain, Luka

AU - Derhovanessian, Evelyna

AU - Ferrando-Martínez, Sara

AU - Frasca, Daniela

AU - Fulöp, Tamas

AU - Govind, Sheila

AU - Grubeck-Loebenstein, Beatrix

AU - Hill, Ann

AU - Hurme, Mikko

AU - Kern, Florian

AU - Larbi, Anis

AU - López-Botet, Miguel

AU - Maier, Andrea B

AU - McElhaney, Janet E

AU - Moss, Paul

AU - Naumova, Elissaveta

AU - Nikolich-Zugich, Janko

AU - Pera, Alejandra

AU - Rector, Jerrald L

AU - Riddell, Natalie

AU - Sanchez-Correa, Beatriz

AU - Sansoni, Paolo

AU - Sauce, Delphine

AU - van Lier, Rene

AU - Wang, George C

AU - Wills, Mark R

AU - Zielinski, Maciej

AU - Pawelec, Graham

AU - Wheatley, Keith

PY - 2012

Y1 - 2012

N2 - ABSTRACT: Alone among herpesviruses, persistent Cytomegalovirus (CMV) markedly alters the numbers and proportions of peripheral immune cells in infected-vs-uninfected people. Because the rate of CMV infection increases with age in most countries, it has been suggested that it drives or at least exacerbates "immunosenescence". This contention remains controversial and was the primary subject of the Third International Workshop on CMV & Immunosenescence which was held in Cordoba, Spain, 15-16th March, 2012. Discussions focused on several main themes including the effects of CMV on adaptive immunity and immunosenescence, characterization of CMV-specific T cells, impact of CMV infection and ageing on innate immunity, and finally, most important, the clinical implications of immunosenescence and CMV infection. Here we summarize the major findings of this workshop.

AB - ABSTRACT: Alone among herpesviruses, persistent Cytomegalovirus (CMV) markedly alters the numbers and proportions of peripheral immune cells in infected-vs-uninfected people. Because the rate of CMV infection increases with age in most countries, it has been suggested that it drives or at least exacerbates "immunosenescence". This contention remains controversial and was the primary subject of the Third International Workshop on CMV & Immunosenescence which was held in Cordoba, Spain, 15-16th March, 2012. Discussions focused on several main themes including the effects of CMV on adaptive immunity and immunosenescence, characterization of CMV-specific T cells, impact of CMV infection and ageing on innate immunity, and finally, most important, the clinical implications of immunosenescence and CMV infection. Here we summarize the major findings of this workshop.

U2 - 10.1186/1742-4933-9-23

DO - 10.1186/1742-4933-9-23

M3 - Article

C2 - 23114110

SN - 1742-4933

VL - 9

SP - 23

JO - Immunity & Ageing

JF - Immunity & Ageing

IS - 1

ER -

CMV and Immunosenescence: from basics to clinics

Abstract

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