Clonal selection in the human Vδ1 T cell repertoire indicates γδ TCR-dependent adaptive immune surveillance

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Clonal selection in the human Vδ1 T cell repertoire indicates γδ TCR-dependent adaptive immune surveillance. / Davey, Martin; Willcox, Carrie; Joyce, Stephen; Ladell, Kristin; Kasatskaya, Sofya A.; McLaren, James E.; Hunter, Stuart; Salim, Mahboob; Mohammed, Fiyaz; Price, David; Chudakov, DM; Willcox, Benjamin.

In: Nature Communications, Vol. 8, 14760, 01.03.2017.

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Davey, Martin ; Willcox, Carrie ; Joyce, Stephen ; Ladell, Kristin ; Kasatskaya, Sofya A. ; McLaren, James E. ; Hunter, Stuart ; Salim, Mahboob ; Mohammed, Fiyaz ; Price, David ; Chudakov, DM ; Willcox, Benjamin. / Clonal selection in the human Vδ1 T cell repertoire indicates γδ TCR-dependent adaptive immune surveillance. In: Nature Communications. 2017 ; Vol. 8.

Bibtex

@article{e190349288164914ab9dea4f0493c724,
title = "Clonal selection in the human Vδ1 T cell repertoire indicates γδ TCR-dependent adaptive immune surveillance",
abstract = "γδ T cells are considered to be innate-like lymphocytes that respond rapidly to stress without clonal selection and differentiation. Here we use next-generation sequencing to probe how this paradigm relates to human Vδ2neg T cells, implicated in responses to viral infection and cancer. The prevalent Vδ1 T cell receptor (TCR) repertoire is private and initially unfocused in cord blood, typically becoming strongly focused on a few high-frequency clonotypes by adulthood. Clonal expansions have differentiated from a naive to effector phenotype associated with CD27 downregulation, retaining proliferative capacity and TCR sensitivity, displaying increased cytotoxic markers and altered homing capabilities, and remaining relatively stable over time. Contrastingly, Vδ2+ T cells express semi-invariant TCRs, which are present at birth and shared between individuals. Human Vδ1+ T cells have therefore evolved a distinct biology from the Vδ2+ subset, involving a central, personalized role for the γδ TCR in directing a highly adaptive yet unconventional form of immune surveillance.",
keywords = "Clonal selection, Gammadelta T cells",
author = "Martin Davey and Carrie Willcox and Stephen Joyce and Kristin Ladell and Kasatskaya, {Sofya A.} and McLaren, {James E.} and Stuart Hunter and Mahboob Salim and Fiyaz Mohammed and David Price and DM Chudakov and Benjamin Willcox",
year = "2017",
month = mar,
day = "1",
doi = "10.1038/ncomms14760",
language = "English",
volume = "8",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "Springer",

}

RIS

TY - JOUR

T1 - Clonal selection in the human Vδ1 T cell repertoire indicates γδ TCR-dependent adaptive immune surveillance

AU - Davey, Martin

AU - Willcox, Carrie

AU - Joyce, Stephen

AU - Ladell, Kristin

AU - Kasatskaya, Sofya A.

AU - McLaren, James E.

AU - Hunter, Stuart

AU - Salim, Mahboob

AU - Mohammed, Fiyaz

AU - Price, David

AU - Chudakov, DM

AU - Willcox, Benjamin

PY - 2017/3/1

Y1 - 2017/3/1

N2 - γδ T cells are considered to be innate-like lymphocytes that respond rapidly to stress without clonal selection and differentiation. Here we use next-generation sequencing to probe how this paradigm relates to human Vδ2neg T cells, implicated in responses to viral infection and cancer. The prevalent Vδ1 T cell receptor (TCR) repertoire is private and initially unfocused in cord blood, typically becoming strongly focused on a few high-frequency clonotypes by adulthood. Clonal expansions have differentiated from a naive to effector phenotype associated with CD27 downregulation, retaining proliferative capacity and TCR sensitivity, displaying increased cytotoxic markers and altered homing capabilities, and remaining relatively stable over time. Contrastingly, Vδ2+ T cells express semi-invariant TCRs, which are present at birth and shared between individuals. Human Vδ1+ T cells have therefore evolved a distinct biology from the Vδ2+ subset, involving a central, personalized role for the γδ TCR in directing a highly adaptive yet unconventional form of immune surveillance.

AB - γδ T cells are considered to be innate-like lymphocytes that respond rapidly to stress without clonal selection and differentiation. Here we use next-generation sequencing to probe how this paradigm relates to human Vδ2neg T cells, implicated in responses to viral infection and cancer. The prevalent Vδ1 T cell receptor (TCR) repertoire is private and initially unfocused in cord blood, typically becoming strongly focused on a few high-frequency clonotypes by adulthood. Clonal expansions have differentiated from a naive to effector phenotype associated with CD27 downregulation, retaining proliferative capacity and TCR sensitivity, displaying increased cytotoxic markers and altered homing capabilities, and remaining relatively stable over time. Contrastingly, Vδ2+ T cells express semi-invariant TCRs, which are present at birth and shared between individuals. Human Vδ1+ T cells have therefore evolved a distinct biology from the Vδ2+ subset, involving a central, personalized role for the γδ TCR in directing a highly adaptive yet unconventional form of immune surveillance.

KW - Clonal selection

KW - Gammadelta T cells

U2 - 10.1038/ncomms14760

DO - 10.1038/ncomms14760

M3 - Article

VL - 8

JO - Nature Communications

JF - Nature Communications

SN - 2041-1723

M1 - 14760

ER -