Clinical Reliability of point-of-care tests to support community based acute ambulatory care

Jan Y. Verbakel; C Richardson; T Elias; J.  Bowen; Roya  Hassanzadeh; B Shine; I Smith; G. N. Hayward; A Van den Bruel; Sarah T  Pendlebury; Dan Lasserson

Clinical Reliability of point-of-care tests to support community based acute ambulatory care

Jan Y. Verbakel, C Richardson, T Elias , J. Bowen, Roya Hassanzadeh, B Shine, I Smith, G. N. Hayward, A Van den Bruel, Sarah T Pendlebury, Dan Lasserson

Applied Health Research

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

Objective: To ensure clinicians can rely on point-of-care testing results, we assessed agreement between point-of-care tests for creatinine, urea, sodium, potassium, calcium, Hb, INR, CRP and subsequent corresponding laboratory tests.

Participants: Community-dwelling adults referred to a community-based acute ambulatory care unit.

Interventions: The Abbott iSTATTM (Hb, clinical chemistry, INR) and the AfinionTM Analyser (CRP) and corresponding laboratory analyses.
Outcomes: Agreement (Bland Altman) and bias (Passing-Bablok regression).

Results: Among 462 adults we found an absolute mean difference between point-of-care and central laboratory analyses of 6.4g/L (95%LOA -7.9 to +20.6) for haemoglobin, -0.5mmol/L (95%LOA -4.5 to +3.5) for sodium, 0.2mmol/L (95%LOA -0.6 to +0.9) for potassium, 0.0mmol/L (95%LOA -0.3 to +0.3) for calcium, 9.0 µmol/L (95%LOA -18.5 to +36.4) for creatinine, 0.0mmol/L (95%LOA -2.7 to +2.6) for urea, -0.2 (95%LOA -2.4 to +2.0) for INR, -5.0 mg/L (95%LOA -24.4 to +14.4) for CRP.

Conclusions: There was acceptable agreement and bias for these analytes, except for haemoglobin and creatinine.

Original language	English
Pages (from-to)	1-60
Number of pages	60
Journal	Acute Medicine
Volume	19
Issue number	1
Publication status	Published - 28 Mar 2020

Keywords

ACUTE CARE
AMBULATORY CARE
CLINICAL ACCURACY
POINT-OF-CARE TESTING
SERVICE EVALUATION

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https://acutemedjournal.co.uk/journal/volume-19/volume-19-issue-1-pages-1-60-2020/clinical-reliability-of-point-of-care-tests-to-support-community-based-acute-ambulatory-care/Licence: None: All rights reserved

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Verbakel, J. Y., Richardson, C., Elias , T., Bowen, J., Hassanzadeh, R., Shine, B., Smith, I., Hayward, G. N., Van den Bruel, A., Pendlebury, S. T., & Lasserson, D. (2020). Clinical Reliability of point-of-care tests to support community based acute ambulatory care. Acute Medicine, 19(1), 1-60. https://acutemedjournal.co.uk/journal/volume-19/volume-19-issue-1-pages-1-60-2020/clinical-reliability-of-point-of-care-tests-to-support-community-based-acute-ambulatory-care/

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title = "Clinical Reliability of point-of-care tests to support community based acute ambulatory care",

abstract = "Objective: To ensure clinicians can rely on point-of-care testing results, we assessed agreement between point-of-care tests for creatinine, urea, sodium, potassium, calcium, Hb, INR, CRP and subsequent corresponding laboratory tests.Participants: Community-dwelling adults referred to a community-based acute ambulatory care unit.Interventions: The Abbott iSTATTM (Hb, clinical chemistry, INR) and the AfinionTM Analyser (CRP) and corresponding laboratory analyses. Outcomes: Agreement (Bland Altman) and bias (Passing-Bablok regression).Results: Among 462 adults we found an absolute mean difference between point-of-care and central laboratory analyses of 6.4g/L (95%LOA -7.9 to +20.6) for haemoglobin, -0.5mmol/L (95%LOA -4.5 to +3.5) for sodium, 0.2mmol/L (95%LOA -0.6 to +0.9) for potassium, 0.0mmol/L (95%LOA -0.3 to +0.3) for calcium, 9.0 µmol/L (95%LOA -18.5 to +36.4) for creatinine, 0.0mmol/L (95%LOA -2.7 to +2.6) for urea, -0.2 (95%LOA -2.4 to +2.0) for INR, -5.0 mg/L (95%LOA -24.4 to +14.4) for CRP.Conclusions: There was acceptable agreement and bias for these analytes, except for haemoglobin and creatinine.",

keywords = "ACUTE CARE, AMBULATORY CARE, CLINICAL ACCURACY, POINT-OF-CARE TESTING, SERVICE EVALUATION",

author = "Verbakel, {Jan Y.} and C Richardson and T Elias and J. Bowen and Roya Hassanzadeh and B Shine and I Smith and Hayward, {G. N.} and {Van den Bruel}, A and Pendlebury, {Sarah T} and Dan Lasserson",

year = "2020",

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Verbakel, JY, Richardson, C, Elias , T, Bowen, J, Hassanzadeh, R, Shine, B, Smith, I, Hayward, GN, Van den Bruel, A, Pendlebury, ST & Lasserson, D 2020, 'Clinical Reliability of point-of-care tests to support community based acute ambulatory care', Acute Medicine, vol. 19, no. 1, pp. 1-60. <https://acutemedjournal.co.uk/journal/volume-19/volume-19-issue-1-pages-1-60-2020/clinical-reliability-of-point-of-care-tests-to-support-community-based-acute-ambulatory-care/>

TY - JOUR

T1 - Clinical Reliability of point-of-care tests to support community based acute ambulatory care

AU - Verbakel, Jan Y.

AU - Richardson, C

AU - Elias , T

AU - Bowen, J.

AU - Hassanzadeh, Roya

AU - Shine, B

AU - Smith, I

AU - Hayward, G. N.

AU - Van den Bruel, A

AU - Pendlebury, Sarah T

AU - Lasserson, Dan

PY - 2020/3/28

Y1 - 2020/3/28

N2 - Objective: To ensure clinicians can rely on point-of-care testing results, we assessed agreement between point-of-care tests for creatinine, urea, sodium, potassium, calcium, Hb, INR, CRP and subsequent corresponding laboratory tests.Participants: Community-dwelling adults referred to a community-based acute ambulatory care unit.Interventions: The Abbott iSTATTM (Hb, clinical chemistry, INR) and the AfinionTM Analyser (CRP) and corresponding laboratory analyses. Outcomes: Agreement (Bland Altman) and bias (Passing-Bablok regression).Results: Among 462 adults we found an absolute mean difference between point-of-care and central laboratory analyses of 6.4g/L (95%LOA -7.9 to +20.6) for haemoglobin, -0.5mmol/L (95%LOA -4.5 to +3.5) for sodium, 0.2mmol/L (95%LOA -0.6 to +0.9) for potassium, 0.0mmol/L (95%LOA -0.3 to +0.3) for calcium, 9.0 µmol/L (95%LOA -18.5 to +36.4) for creatinine, 0.0mmol/L (95%LOA -2.7 to +2.6) for urea, -0.2 (95%LOA -2.4 to +2.0) for INR, -5.0 mg/L (95%LOA -24.4 to +14.4) for CRP.Conclusions: There was acceptable agreement and bias for these analytes, except for haemoglobin and creatinine.

AB - Objective: To ensure clinicians can rely on point-of-care testing results, we assessed agreement between point-of-care tests for creatinine, urea, sodium, potassium, calcium, Hb, INR, CRP and subsequent corresponding laboratory tests.Participants: Community-dwelling adults referred to a community-based acute ambulatory care unit.Interventions: The Abbott iSTATTM (Hb, clinical chemistry, INR) and the AfinionTM Analyser (CRP) and corresponding laboratory analyses. Outcomes: Agreement (Bland Altman) and bias (Passing-Bablok regression).Results: Among 462 adults we found an absolute mean difference between point-of-care and central laboratory analyses of 6.4g/L (95%LOA -7.9 to +20.6) for haemoglobin, -0.5mmol/L (95%LOA -4.5 to +3.5) for sodium, 0.2mmol/L (95%LOA -0.6 to +0.9) for potassium, 0.0mmol/L (95%LOA -0.3 to +0.3) for calcium, 9.0 µmol/L (95%LOA -18.5 to +36.4) for creatinine, 0.0mmol/L (95%LOA -2.7 to +2.6) for urea, -0.2 (95%LOA -2.4 to +2.0) for INR, -5.0 mg/L (95%LOA -24.4 to +14.4) for CRP.Conclusions: There was acceptable agreement and bias for these analytes, except for haemoglobin and creatinine.

KW - ACUTE CARE

KW - AMBULATORY CARE

KW - CLINICAL ACCURACY

KW - POINT-OF-CARE TESTING

KW - SERVICE EVALUATION

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M3 - Article

SN - 1747-4884

VL - 19

SP - 1

EP - 60

JO - Acute Medicine

JF - Acute Medicine

IS - 1

ER -

Clinical Reliability of point-of-care tests to support community based acute ambulatory care

Abstract

Keywords

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