Clinical proton MR spectroscopy in central nervous system disorders

Research output: Contribution to journalReview articlepeer-review


  • Gülin Oz
  • Jeffry R Alger
  • Peter B Barker
  • Robert Bartha
  • Alberto Bizzi
  • Chris Boesch
  • Patrick J Bolan
  • Kevin M Brindle
  • Cristina Cudalbu
  • Alp Dinçer
  • Ulrike Dydak
  • Uzay E Emir
  • Jens Frahm
  • Ramón Gilberto González
  • Stephan Gruber
  • Rolf Gruetter
  • Rakesh K Gupta
  • Arend Heerschap
  • Anke Henning
  • Hoby P Hetherington
  • Franklyn A Howe
  • Petra S Hüppi
  • Ralph E Hurd
  • Kantarci Kantarci
  • Dennis W J Klomp
  • Roland Kreis
  • Marijn J Kruiskamp
  • Martin O Leach
  • Alexander P Lin
  • Peter R Luijten
  • Malgorzata Marjańska
  • Andrew A Maudsley
  • Dieter J Meyerhoff
  • Carolyn E Mountford
  • Sarah J Nelson
  • M Necmettin Pamir
  • Jullie W Pan
  • Andrew Peet
  • Harish Poptani
  • Stefan Posse
  • Petra J W Pouwels
  • Eva-Maria Ratai
  • Brian D Ross
  • Tom W Scheenen
  • Christian Schuster
  • Ian C P Smith
  • Brian J Soher
  • Ivan Tkáč
  • Daniel B Vigneron
  • Risto Kauppinen
  • MRS Consensus Group

External organisations

  • University of Minnesota


A large body of published work shows that proton (hydrogen 1 [(1)H]) magnetic resonance (MR) spectroscopy has evolved from a research tool into a clinical neuroimaging modality. Herein, the authors present a summary of brain disorders in which MR spectroscopy has an impact on patient management, together with a critical consideration of common data acquisition and processing procedures. The article documents the impact of (1)H MR spectroscopy in the clinical evaluation of disorders of the central nervous system. The clinical usefulness of (1)H MR spectroscopy has been established for brain neoplasms, neonatal and pediatric disorders (hypoxia-ischemia, inherited metabolic diseases, and traumatic brain injury), demyelinating disorders, and infectious brain lesions. The growing list of disorders for which (1)H MR spectroscopy may contribute to patient management extends to neurodegenerative diseases, epilepsy, and stroke. To facilitate expanded clinical acceptance and standardization of MR spectroscopy methodology, guidelines are provided for data acquisition and analysis, quality assessment, and interpretation. Finally, the authors offer recommendations to expedite the use of robust MR spectroscopy methodology in the clinical setting, including incorporation of technical advances on clinical units.


Original languageEnglish
Pages (from-to)658-679
Number of pages22
Issue number3
Publication statusPublished - 1 Mar 2014


  • Biomarkers, Central Nervous System Diseases, Humans, Magnetic Resonance Spectroscopy, Journal Article, Research Support, Non-U.S. Gov't, Review