Clinical, immunological, and epidemiological importance of antituberculosis T cell responses in HIV-infected Africans

Molebogeng X Rangaka; Lavanya Diwakar; Ronnett Seldon; Gilles van Cutsem; Graeme A Meintjes; Chelsea Morroni; Priscilla Mouton; Muki S Shey; Gary Maartens; Katalin A Wilkinson; Robert J Wilkinson; Lavanya Diwakar

doi:10.1086/518234

Clinical, immunological, and epidemiological importance of antituberculosis T cell responses in HIV-infected Africans

Molebogeng X Rangaka, Lavanya Diwakar, Ronnett Seldon, Gilles van Cutsem, Graeme A Meintjes, Chelsea Morroni, Priscilla Mouton, Muki S Shey, Gary Maartens, Katalin A Wilkinson, Robert J Wilkinson, Lavanya Diwakar

Applied Health Research

Research output: Contribution to journal › Article › peer-review

71 Citations (Scopus)

Abstract

Human immunodeficiency virus (HIV)-associated tuberculosis is a major cause of mortality in Africa. The assay of T cell interferon- gamma released in response to antigens of greater specificity than purified protein derivative is a useful improvement over the Mantoux tuberculin skin test, but few studies have evaluated interferon-gamma secretion in HIV-infected individuals.

Original language	English
Pages (from-to)	1639-46
Number of pages	8
Journal	Clinical Infectious Diseases
Volume	44
Issue number	12
DOIs	https://doi.org/10.1086/518234
Publication status	Published - 15 Jun 2007

Keywords

AIDS-Related Opportunistic Infections
Adult
Antigens, Bacterial
CD4 Lymphocyte Count
Enzyme-Linked Immunosorbent Assay
Female
HIV Infections
Humans
Interferon-gamma
Male
Middle Aged
South Africa
T-Lymphocytes
Tuberculin Test
Tuberculosis

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1086/518234

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Rangaka, M. X., Diwakar, L., Seldon, R., van Cutsem, G., Meintjes, G. A., Morroni, C., Mouton, P., Shey, M. S., Maartens, G., Wilkinson, K. A., Wilkinson, R. J., & Diwakar, L. (2007). Clinical, immunological, and epidemiological importance of antituberculosis T cell responses in HIV-infected Africans. Clinical Infectious Diseases, 44(12), 1639-46. https://doi.org/10.1086/518234

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abstract = "Human immunodeficiency virus (HIV)-associated tuberculosis is a major cause of mortality in Africa. The assay of T cell interferon- gamma released in response to antigens of greater specificity than purified protein derivative is a useful improvement over the Mantoux tuberculin skin test, but few studies have evaluated interferon-gamma secretion in HIV-infected individuals.",

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author = "Rangaka, {Molebogeng X} and Lavanya Diwakar and Ronnett Seldon and {van Cutsem}, Gilles and Meintjes, {Graeme A} and Chelsea Morroni and Priscilla Mouton and Shey, {Muki S} and Gary Maartens and Wilkinson, {Katalin A} and Wilkinson, {Robert J} and Lavanya Diwakar",

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Rangaka, MX, Diwakar, L, Seldon, R, van Cutsem, G, Meintjes, GA, Morroni, C, Mouton, P, Shey, MS, Maartens, G, Wilkinson, KA, Wilkinson, RJ & Diwakar, L 2007, 'Clinical, immunological, and epidemiological importance of antituberculosis T cell responses in HIV-infected Africans', Clinical Infectious Diseases, vol. 44, no. 12, pp. 1639-46. https://doi.org/10.1086/518234

TY - JOUR

T1 - Clinical, immunological, and epidemiological importance of antituberculosis T cell responses in HIV-infected Africans

AU - Rangaka, Molebogeng X

AU - Diwakar, Lavanya

AU - Seldon, Ronnett

AU - van Cutsem, Gilles

AU - Meintjes, Graeme A

AU - Morroni, Chelsea

AU - Mouton, Priscilla

AU - Shey, Muki S

AU - Maartens, Gary

AU - Wilkinson, Katalin A

AU - Wilkinson, Robert J

AU - Diwakar, Lavanya

PY - 2007/6/15

Y1 - 2007/6/15

N2 - Human immunodeficiency virus (HIV)-associated tuberculosis is a major cause of mortality in Africa. The assay of T cell interferon- gamma released in response to antigens of greater specificity than purified protein derivative is a useful improvement over the Mantoux tuberculin skin test, but few studies have evaluated interferon-gamma secretion in HIV-infected individuals.

AB - Human immunodeficiency virus (HIV)-associated tuberculosis is a major cause of mortality in Africa. The assay of T cell interferon- gamma released in response to antigens of greater specificity than purified protein derivative is a useful improvement over the Mantoux tuberculin skin test, but few studies have evaluated interferon-gamma secretion in HIV-infected individuals.

KW - AIDS-Related Opportunistic Infections

KW - Adult

KW - Antigens, Bacterial

KW - CD4 Lymphocyte Count

KW - Enzyme-Linked Immunosorbent Assay

KW - Female

KW - HIV Infections

KW - Humans

KW - Interferon-gamma

KW - Male

KW - Middle Aged

KW - South Africa

KW - T-Lymphocytes

KW - Tuberculin Test

KW - Tuberculosis

U2 - 10.1086/518234

DO - 10.1086/518234

M3 - Article

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SN - 1058-4838

VL - 44

SP - 1639

EP - 1646

JO - Clinical Infectious Diseases

JF - Clinical Infectious Diseases

IS - 12

ER -

Clinical, immunological, and epidemiological importance of antituberculosis T cell responses in HIV-infected Africans

Abstract

Keywords

UN SDGs

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