Clinical, immunological, and epidemiological importance of antituberculosis T cell responses in HIV-infected Africans

Research output: Contribution to journalArticle

Authors

  • Molebogeng X Rangaka
  • Lavanya Diwakar
  • Ronnett Seldon
  • Gilles van Cutsem
  • Graeme A Meintjes
  • Chelsea Morroni
  • Priscilla Mouton
  • Muki S Shey
  • Gary Maartens
  • Katalin A Wilkinson
  • Robert J Wilkinson

Colleges, School and Institutes

External organisations

  • Institute of Infectious Diseases and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.

Abstract

Human immunodeficiency virus (HIV)-associated tuberculosis is a major cause of mortality in Africa. The assay of T cell interferon- gamma released in response to antigens of greater specificity than purified protein derivative is a useful improvement over the Mantoux tuberculin skin test, but few studies have evaluated interferon-gamma secretion in HIV-infected individuals.

Details

Original languageEnglish
Pages (from-to)1639-46
Number of pages8
JournalClinical Infectious Diseases
Volume44
Issue number12
Publication statusPublished - 15 Jun 2007

Keywords

  • AIDS-Related Opportunistic Infections, Adult, Antigens, Bacterial, CD4 Lymphocyte Count, Enzyme-Linked Immunosorbent Assay, Female, HIV Infections, Humans, Interferon-gamma, Male, Middle Aged, South Africa, T-Lymphocytes, Tuberculin Test, Tuberculosis