Clinical and economic assessment of different general population strategies of pertussis vaccine booster regarding number of doses and age of application for reducing whooping cough disease burden: A systematic review

Research output: Contribution to journalReview article


Colleges, School and Institutes


Pertussis continues to be an important cause of morbidity and mortality in children too young to be fully protected despite high vaccination coverage. This has been attributed to waning immunity in older people, leading to the development of strategies to increase levels of immunity. A systematic review was conducted to assess the clinical and cost effectiveness of four population-based strategies for pertussis booster vaccination: single booster at 12-24 months old, single pre-school booster, single adolescent booster and Multiple boosters in adulthood every 10 years. Electronic databases and Internet resources were searched to June 2006. Nine observational studies, four mathematical models and eight economic evaluations were included, evaluating four different strategies. Strong evidence to recommend any of these strategies was not found. (C) 2008 Elsevier Ltd. All rights reserved.


Original languageEnglish
Pages (from-to)6768-6776
Number of pages9
Issue number52
Publication statusPublished - 1 Dec 2008


  • Pertussis vaccination, Systematic review, Economic evaluation, Booster strategy