Classification, functions, and clinical relevance of extracellular vesicles

Research output: Contribution to journalArticlepeer-review

Standard

Classification, functions, and clinical relevance of extracellular vesicles. / van der Pol, Edwin; Böing, Anita N; Harrison, Paul; Sturk, Augueste; Nieuwland, Rienk.

In: Pharmacological Reviews, Vol. 64, No. 3, 07.2012, p. 676-705.

Research output: Contribution to journalArticlepeer-review

Harvard

APA

Vancouver

Author

van der Pol, Edwin ; Böing, Anita N ; Harrison, Paul ; Sturk, Augueste ; Nieuwland, Rienk. / Classification, functions, and clinical relevance of extracellular vesicles. In: Pharmacological Reviews. 2012 ; Vol. 64, No. 3. pp. 676-705.

Bibtex

@article{dd04237c3a284c258ee7fe33515dbe1b,
title = "Classification, functions, and clinical relevance of extracellular vesicles",
abstract = "Both eukaryotic and prokaryotic cells release small, phospholipid-enclosed vesicles into their environment. Why do cells release vesicles? Initial studies showed that eukaryotic vesicles are used to remove obsolete cellular molecules. Although this release of vesicles is beneficial to the cell, the vesicles can also be a danger to their environment, for instance in blood, where vesicles can provide a surface supporting coagulation. Evidence is accumulating that vesicles are cargo containers used by eukaryotic cells to exchange biomolecules as transmembrane receptors and genetic information. Because also bacteria communicate to each other via extracellular vesicles, the intercellular communication via extracellular cargo carriers seems to be conserved throughout evolution, and therefore vesicles are likely to be a highly efficient, robust, and economic manner of exchanging information between cells. Furthermore, vesicles protect cells from accumulation of waste or drugs, they contribute to physiology and pathology, and they have a myriad of potential clinical applications, ranging from biomarkers to anticancer therapy. Because vesicles may pass the blood-brain barrier, they can perhaps even be considered naturally occurring liposomes. Unfortunately, pathways of vesicle release and vesicles themselves are also being used by tumors and infectious diseases to facilitate spreading, and to escape from immune surveillance. In this review, the different types, nomenclature, functions, and clinical relevance of vesicles will be discussed.",
keywords = "Animals, Biological Markers, Blood-Brain Barrier, Cell Communication, Cell-Derived Microparticles, Exosomes, Humans, Microscopy, Electron, Transmission, Neoplasms, Terminology as Topic",
author = "{van der Pol}, Edwin and B{\"o}ing, {Anita N} and Paul Harrison and Augueste Sturk and Rienk Nieuwland",
year = "2012",
month = jul,
doi = "10.1124/pr.112.005983",
language = "English",
volume = "64",
pages = "676--705",
journal = "Pharmacological Reviews",
issn = "0031-6997",
publisher = "American Society for Pharmacology and Experimental Therapeutics",
number = "3",

}

RIS

TY - JOUR

T1 - Classification, functions, and clinical relevance of extracellular vesicles

AU - van der Pol, Edwin

AU - Böing, Anita N

AU - Harrison, Paul

AU - Sturk, Augueste

AU - Nieuwland, Rienk

PY - 2012/7

Y1 - 2012/7

N2 - Both eukaryotic and prokaryotic cells release small, phospholipid-enclosed vesicles into their environment. Why do cells release vesicles? Initial studies showed that eukaryotic vesicles are used to remove obsolete cellular molecules. Although this release of vesicles is beneficial to the cell, the vesicles can also be a danger to their environment, for instance in blood, where vesicles can provide a surface supporting coagulation. Evidence is accumulating that vesicles are cargo containers used by eukaryotic cells to exchange biomolecules as transmembrane receptors and genetic information. Because also bacteria communicate to each other via extracellular vesicles, the intercellular communication via extracellular cargo carriers seems to be conserved throughout evolution, and therefore vesicles are likely to be a highly efficient, robust, and economic manner of exchanging information between cells. Furthermore, vesicles protect cells from accumulation of waste or drugs, they contribute to physiology and pathology, and they have a myriad of potential clinical applications, ranging from biomarkers to anticancer therapy. Because vesicles may pass the blood-brain barrier, they can perhaps even be considered naturally occurring liposomes. Unfortunately, pathways of vesicle release and vesicles themselves are also being used by tumors and infectious diseases to facilitate spreading, and to escape from immune surveillance. In this review, the different types, nomenclature, functions, and clinical relevance of vesicles will be discussed.

AB - Both eukaryotic and prokaryotic cells release small, phospholipid-enclosed vesicles into their environment. Why do cells release vesicles? Initial studies showed that eukaryotic vesicles are used to remove obsolete cellular molecules. Although this release of vesicles is beneficial to the cell, the vesicles can also be a danger to their environment, for instance in blood, where vesicles can provide a surface supporting coagulation. Evidence is accumulating that vesicles are cargo containers used by eukaryotic cells to exchange biomolecules as transmembrane receptors and genetic information. Because also bacteria communicate to each other via extracellular vesicles, the intercellular communication via extracellular cargo carriers seems to be conserved throughout evolution, and therefore vesicles are likely to be a highly efficient, robust, and economic manner of exchanging information between cells. Furthermore, vesicles protect cells from accumulation of waste or drugs, they contribute to physiology and pathology, and they have a myriad of potential clinical applications, ranging from biomarkers to anticancer therapy. Because vesicles may pass the blood-brain barrier, they can perhaps even be considered naturally occurring liposomes. Unfortunately, pathways of vesicle release and vesicles themselves are also being used by tumors and infectious diseases to facilitate spreading, and to escape from immune surveillance. In this review, the different types, nomenclature, functions, and clinical relevance of vesicles will be discussed.

KW - Animals

KW - Biological Markers

KW - Blood-Brain Barrier

KW - Cell Communication

KW - Cell-Derived Microparticles

KW - Exosomes

KW - Humans

KW - Microscopy, Electron, Transmission

KW - Neoplasms

KW - Terminology as Topic

U2 - 10.1124/pr.112.005983

DO - 10.1124/pr.112.005983

M3 - Article

C2 - 22722893

VL - 64

SP - 676

EP - 705

JO - Pharmacological Reviews

JF - Pharmacological Reviews

SN - 0031-6997

IS - 3

ER -