Clarithromycin as an adjunct to periodontal therapy: a systematic review and meta-analysis

Research output: Contribution to journalReview articlepeer-review

Authors

Colleges, School and Institutes

Abstract

OBJECTIVE: To collate the literature evaluating the efficacy of clarithromycin as an adjunct to non-surgical periodontal therapy and conduct meta-analyses for changes in probing pocket depth (PPD) and clinical attachment level (CAL).

METHODS: Five electronic databases were searched from inception to May 2020 (PubMed, Cochrane CENTRAL, EMBASE via OVID, Web of Science and OpenGrey). Clinical outcomes were extracted, pooled and meta-analyses conducted using mean difference with standard deviations.

RESULTS: Systemic delivery: 0.65 mm (95% CI: 0.02 to 1.27 mm) mean additional PPD reduction was observed at 3 months and 0.28 mm (95% CI: -0.32 to 0.87 mm) at 6 months. 0.41 mm (95% CI: -0.12 to 0.95 mm) mean additional CAL gain was observed at 3 months, and 0.16 mm (95% CI: -0.41 to 0.74 mm) at 6 months. Increased risk of adverse events was observed; RR: 5.13 (95% CI: 0.63 to 41.98). Local delivery: 1.01 mm (95% CI: 0.84 to 1.17 mm) mean additional PPD reduction was observed at 3 months, and 1.20 mm (95% CI: 0.76 to 1.64 mm) at 6 months. 0.56 mm (95% CI: 0.46 to 0.66 mm) mean additional CAL gain was observed at 3 months, and 0.83 mm (95% CI: 0.65 to 1.02 mm) at 6 months. No adverse events were observed.

CONCLUSIONS: The use of locally delivered clarithromycin significantly improves treatment outcomes.

Bibliographic note

© 2021 The Authors. International Journal of Dental Hygiene published by John Wiley & Sons Ltd.

Details

Original languageEnglish
JournalInternational Journal of Dental Hygiene
Early online date26 Mar 2021
Publication statusE-pub ahead of print - 26 Mar 2021

Keywords

  • anti-bacterial agents, clarithromycin, periodontitis, root surface debridement, treatment outcome