Clarithromycin alone and in combination with ceftriaxone inhibits the production of pneumolysin by both macrolide-susceptible and macrolide-resistant strains of Streptococcus pneumoniae

R Anderson; H C Steel; R Cockeran; A M Smith; A von Gottberg; L de Gouveia; A Brink; K P Klugman; T J Mitchell; C Feldman

doi:10.1093/jac/dkl479

Clarithromycin alone and in combination with ceftriaxone inhibits the production of pneumolysin by both macrolide-susceptible and macrolide-resistant strains of Streptococcus pneumoniae

R Anderson, H C Steel, R Cockeran, A M Smith, A von Gottberg, L de Gouveia, A Brink, K P Klugman, T J Mitchell, C Feldman

Immunology and Immunotherapy

Research output: Contribution to journal › Article › peer-review

34 Citations (Scopus)

Abstract

To investigate the effects of clarithromycin (0.01-0.5 mg/L) alone or in combination with ceftriaxone (0.1 and 0.25 mg/L) on pneumolysin production by both macrolide-susceptible and -resistant [2 erm(B) positive and 2 mef(A) positive] strains of Streptococcus pneumoniae.

Original language	English
Pages (from-to)	224-9
Number of pages	6
Journal	Journal of Antimicrobial Chemotherapy
Volume	59
Issue number	2
DOIs	https://doi.org/10.1093/jac/dkl479
Publication status	Published - Feb 2007

Keywords

Anti-Bacterial Agents
Bacterial Proteins
Ceftriaxone
Clarithromycin
Dose-Response Relationship, Drug
Drug Resistance, Bacterial
Drug Synergism
Microbial Sensitivity Tests
Polymerase Chain Reaction
Streptococcus pneumoniae
Streptolysins

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10.1093/jac/dkl479

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Anderson, R., Steel, H. C., Cockeran, R., Smith, A. M., von Gottberg, A., de Gouveia, L., Brink, A., Klugman, K. P., Mitchell, T. J., & Feldman, C. (2007). Clarithromycin alone and in combination with ceftriaxone inhibits the production of pneumolysin by both macrolide-susceptible and macrolide-resistant strains of Streptococcus pneumoniae. Journal of Antimicrobial Chemotherapy, 59(2), 224-9. https://doi.org/10.1093/jac/dkl479

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title = "Clarithromycin alone and in combination with ceftriaxone inhibits the production of pneumolysin by both macrolide-susceptible and macrolide-resistant strains of Streptococcus pneumoniae",

abstract = "To investigate the effects of clarithromycin (0.01-0.5 mg/L) alone or in combination with ceftriaxone (0.1 and 0.25 mg/L) on pneumolysin production by both macrolide-susceptible and -resistant [2 erm(B) positive and 2 mef(A) positive] strains of Streptococcus pneumoniae.",

keywords = "Anti-Bacterial Agents, Bacterial Proteins, Ceftriaxone, Clarithromycin, Dose-Response Relationship, Drug, Drug Resistance, Bacterial, Drug Synergism, Microbial Sensitivity Tests, Polymerase Chain Reaction, Streptococcus pneumoniae, Streptolysins",

author = "R Anderson and Steel, {H C} and R Cockeran and Smith, {A M} and {von Gottberg}, A and {de Gouveia}, L and A Brink and Klugman, {K P} and Mitchell, {T J} and C Feldman",

year = "2007",

month = feb,

doi = "10.1093/jac/dkl479",

language = "English",

volume = "59",

pages = "224--9",

journal = "Journal of Antimicrobial Chemotherapy",

issn = "0305-7453",

publisher = "Oxford University Press",

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Anderson, R, Steel, HC, Cockeran, R, Smith, AM, von Gottberg, A, de Gouveia, L, Brink, A, Klugman, KP, Mitchell, TJ & Feldman, C 2007, 'Clarithromycin alone and in combination with ceftriaxone inhibits the production of pneumolysin by both macrolide-susceptible and macrolide-resistant strains of Streptococcus pneumoniae', Journal of Antimicrobial Chemotherapy, vol. 59, no. 2, pp. 224-9. https://doi.org/10.1093/jac/dkl479

Clarithromycin alone and in combination with ceftriaxone inhibits the production of pneumolysin by both macrolide-susceptible and macrolide-resistant strains of Streptococcus pneumoniae. / Anderson, R; Steel, H C; Cockeran, R et al.
In: Journal of Antimicrobial Chemotherapy, Vol. 59, No. 2, 02.2007, p. 224-9.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Clarithromycin alone and in combination with ceftriaxone inhibits the production of pneumolysin by both macrolide-susceptible and macrolide-resistant strains of Streptococcus pneumoniae

AU - Anderson, R

AU - Steel, H C

AU - Cockeran, R

AU - Smith, A M

AU - von Gottberg, A

AU - de Gouveia, L

AU - Brink, A

AU - Klugman, K P

AU - Mitchell, T J

AU - Feldman, C

PY - 2007/2

Y1 - 2007/2

N2 - To investigate the effects of clarithromycin (0.01-0.5 mg/L) alone or in combination with ceftriaxone (0.1 and 0.25 mg/L) on pneumolysin production by both macrolide-susceptible and -resistant [2 erm(B) positive and 2 mef(A) positive] strains of Streptococcus pneumoniae.

AB - To investigate the effects of clarithromycin (0.01-0.5 mg/L) alone or in combination with ceftriaxone (0.1 and 0.25 mg/L) on pneumolysin production by both macrolide-susceptible and -resistant [2 erm(B) positive and 2 mef(A) positive] strains of Streptococcus pneumoniae.

KW - Anti-Bacterial Agents

KW - Bacterial Proteins

KW - Ceftriaxone

KW - Clarithromycin

KW - Dose-Response Relationship, Drug

KW - Drug Resistance, Bacterial

KW - Drug Synergism

KW - Microbial Sensitivity Tests

KW - Polymerase Chain Reaction

KW - Streptococcus pneumoniae

KW - Streptolysins

U2 - 10.1093/jac/dkl479

DO - 10.1093/jac/dkl479

M3 - Article

C2 - 17218449

SN - 0305-7453

VL - 59

SP - 224

EP - 229

JO - Journal of Antimicrobial Chemotherapy

JF - Journal of Antimicrobial Chemotherapy

IS - 2

ER -

Clarithromycin alone and in combination with ceftriaxone inhibits the production of pneumolysin by both macrolide-susceptible and macrolide-resistant strains of Streptococcus pneumoniae

Abstract

Keywords

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