Clarithromycin alone and in combination with ceftriaxone inhibits the production of pneumolysin by both macrolide-susceptible and macrolide-resistant strains of Streptococcus pneumoniae

Research output: Contribution to journalArticlepeer-review


  • H C Steel
  • R Cockeran
  • A M Smith
  • A von Gottberg
  • L de Gouveia
  • A Brink
  • K P Klugman
  • C Feldman

Colleges, School and Institutes


To investigate the effects of clarithromycin (0.01-0.5 mg/L) alone or in combination with ceftriaxone (0.1 and 0.25 mg/L) on pneumolysin production by both macrolide-susceptible and -resistant [2 erm(B) positive and 2 mef(A) positive] strains of Streptococcus pneumoniae.


Original languageEnglish
Pages (from-to)224-9
Number of pages6
JournalJournal of Antimicrobial Chemotherapy
Issue number2
Publication statusPublished - Feb 2007


  • Anti-Bacterial Agents, Bacterial Proteins, Ceftriaxone, Clarithromycin, Dose-Response Relationship, Drug, Drug Resistance, Bacterial, Drug Synergism, Microbial Sensitivity Tests, Polymerase Chain Reaction, Streptococcus pneumoniae, Streptolysins