Cisplatin adducts of DNA as precursors for nanostructured catalyst materials

Klaudia Englert; Ruba Hendi; Peter H. Robbs; Neil V. Rees; Alex P. G. Robinson; James H. R. Tucker

doi:10.1039/d0na00528b

Cisplatin adducts of DNA as precursors for nanostructured catalyst materials

Klaudia Englert, Ruba Hendi, Peter H. Robbs, Neil V. Rees, Alex P. G. Robinson, James H. R. Tucker^*

^*Corresponding author for this work

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Abstract

The synthesis and characterisation of novel metal-modified DNA precursors for fuel cell catalyst development are described. Material precursors in the form of metal-DNA complexes were prepared through the reaction of DNA with cisplatin at various loadings and spectroscopically tested to confirm the platinum binding mode and the degree of complexation. The surface morphology of the DNA-metal material was analysed by Scanning Transmission Electron Microscopy (STEM), which revealed the extent of platinum nanocluster formation, with low metal loadings leading to observation of individual platinum atoms. Electrochemical measurements showed a greater electrocatalytic activity for the hydrogen evolution reaction (HER) with increased platinum loadings, shifting the half wave potential, E1/2, away from the glassy carbon limit towards that of a bulk Pt electrode. This is explained further by Tafel plots, from which a change in the mechanism of the apparent rate limiting step for proton reduction from a Volmer to a Heyrovsky mechanism is postulated as the platinum loading increases. This journal is

Original language	English
Pages (from-to)	4491-4497
Number of pages	7
Journal	Nanoscale Advances
Volume	2
Issue number	10
Early online date	24 Aug 2020
DOIs	https://doi.org/10.1039/d0na00528b
Publication status	Published - 24 Aug 2020

Bibliographical note

Funding Information:
The authors wish to thank the DSTL for the award of a PhD studentship through CDE funding to K. E. (project title: DNA Origami Catalysts, contract number: DSTLX-1000098487). The School of Chemical Engineering is also acknowledged for the award of a PhD studentship to R. H. The Centre for Chemical and Materials Analysis in the School of Chemistry is acknowledged for technical support. We would like to acknowledge the assistance of Dr Wolfgang Thesis with the STEM imaging.

Publisher Copyright:
© The Royal Society of Chemistry.

Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.

ASJC Scopus subject areas

Engineering(all)
Bioengineering
Atomic and Molecular Physics, and Optics
Materials Science(all)
Chemistry(all)

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EnglertK2020CisplatinFinal published version, 1.85 MBLicence: Creative Commons: Attribution (CC BY)

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title = "Cisplatin adducts of DNA as precursors for nanostructured catalyst materials",

abstract = "The synthesis and characterisation of novel metal-modified DNA precursors for fuel cell catalyst development are described. Material precursors in the form of metal-DNA complexes were prepared through the reaction of DNA with cisplatin at various loadings and spectroscopically tested to confirm the platinum binding mode and the degree of complexation. The surface morphology of the DNA-metal material was analysed by Scanning Transmission Electron Microscopy (STEM), which revealed the extent of platinum nanocluster formation, with low metal loadings leading to observation of individual platinum atoms. Electrochemical measurements showed a greater electrocatalytic activity for the hydrogen evolution reaction (HER) with increased platinum loadings, shifting the half wave potential, E1/2, away from the glassy carbon limit towards that of a bulk Pt electrode. This is explained further by Tafel plots, from which a change in the mechanism of the apparent rate limiting step for proton reduction from a Volmer to a Heyrovsky mechanism is postulated as the platinum loading increases. This journal is",

author = "Klaudia Englert and Ruba Hendi and Robbs, {Peter H.} and Rees, {Neil V.} and Robinson, {Alex P. G.} and Tucker, {James H. R.}",

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AU - Tucker, James H. R.

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N2 - The synthesis and characterisation of novel metal-modified DNA precursors for fuel cell catalyst development are described. Material precursors in the form of metal-DNA complexes were prepared through the reaction of DNA with cisplatin at various loadings and spectroscopically tested to confirm the platinum binding mode and the degree of complexation. The surface morphology of the DNA-metal material was analysed by Scanning Transmission Electron Microscopy (STEM), which revealed the extent of platinum nanocluster formation, with low metal loadings leading to observation of individual platinum atoms. Electrochemical measurements showed a greater electrocatalytic activity for the hydrogen evolution reaction (HER) with increased platinum loadings, shifting the half wave potential, E1/2, away from the glassy carbon limit towards that of a bulk Pt electrode. This is explained further by Tafel plots, from which a change in the mechanism of the apparent rate limiting step for proton reduction from a Volmer to a Heyrovsky mechanism is postulated as the platinum loading increases. This journal is

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Cisplatin adducts of DNA as precursors for nanostructured catalyst materials

Abstract

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