Circulating tumor DNA as a biomarker and liquid biopsy in head and neck squamous cell carcinoma

Research output: Contribution to journalArticle

Authors

  • Karl Payne
  • Neil Sharma
  • Anthony Kong
  • Timothy Martin
  • Satyesh Parmar
  • Prav Praveen

External organisations

  • Translational Laboratory Team, University of Birmingham, Birmingham, United Kingdom.
  • Department of Oral and Maxillofacial Surgery, Queen Elizabeth Hospital
  • Department of Head and Neck Surgery, Queen Elizabeth Hospital
  • Department of Clinical Oncology, Queen Elizabeth Hospital

Abstract

The use of circulating biochemical molecular markers in head and neck cancer holds the promise of improved diagnostics, treatment planning, and posttreatment surveillance. In this review, we provide an introduction for the head and neck surgeon of the basic science, current evidence, and future applications of circulating tumor DNA (ctDNA) as a biomarker and liquid biopsy to detect tumor genetic heterogeneity in patients with head and neck squamous cell carcinoma (HNSCC).

Bibliographic note

Payne K, Spruce R, Beggs A, et al. Circulating tumor DNA as a biomarker and liquid biopsy in head and neck squamous cell carcinoma. Head & Neck. 2018;40:1598–1604. https://doi.org/10.1002/hed.25140

Details

Original languageEnglish
Pages (from-to)1598-1604
Number of pages7
JournalHead & Neck
Volume40
Issue number7
Early online date15 Mar 2018
Publication statusPublished - 1 Jul 2018

Keywords

  • Journal Article, biomarker , circulating tumor DNA (ctDNA), head and neck cancer , liquid biopsy