Circulating soluble vascular adhesion protein 1 accounts for the increased serum monoamine oxidase activity in chronic liver disease

R Kurkijärvi, G G Yegutkin, B K Gunson, S Jalkanen, M Salmi, David Adams

Research output: Contribution to journalArticlepeer-review

84 Citations (Scopus)

Abstract

Vascular adhesion protein 1 (VAP-1) is an endothelial glycoprotein that supports adhesion of lymphocytes to hepatic endothelium and has sequence homology with semicarbazide-sensitive amine oxidases (SSAOs). We investigated whether soluble VAP-1 (sVAP-1) displays SSAO activity and thereby accounts for increased monoamine oxidase activity in the serum of patients with liver diseases.
Original languageEnglish
Pages (from-to)1096-103
Number of pages8
JournalGastroenterology
Volume119
Issue number4
Publication statusPublished - Oct 2000

Keywords

  • Amine Oxidase (Copper-Containing)
  • Aspartate Aminotransferases
  • Bile
  • Bilirubin
  • Biological Markers
  • Carcinoma, Hepatocellular
  • Cell Adhesion Molecules
  • Chronic Disease
  • Colorectal Neoplasms
  • Creatinine
  • Enzyme-Linked Immunosorbent Assay
  • Hepatitis
  • Hepatitis, Alcoholic
  • Humans
  • Liver Circulation
  • Liver Cirrhosis, Alcoholic
  • Liver Diseases
  • Liver Failure, Acute
  • Liver Neoplasms
  • Liver Transplantation
  • Monoamine Oxidase
  • Portal System
  • Reference Values
  • Sialoglycoproteins

Fingerprint

Dive into the research topics of 'Circulating soluble vascular adhesion protein 1 accounts for the increased serum monoamine oxidase activity in chronic liver disease'. Together they form a unique fingerprint.

Cite this