Circulating soluble vascular adhesion protein 1 accounts for the increased serum monoamine oxidase activity in chronic liver disease

Research output: Contribution to journalArticle

Authors

  • R Kurkijärvi
  • G G Yegutkin
  • B K Gunson
  • S Jalkanen
  • M Salmi
  • D H Adams

Abstract

Vascular adhesion protein 1 (VAP-1) is an endothelial glycoprotein that supports adhesion of lymphocytes to hepatic endothelium and has sequence homology with semicarbazide-sensitive amine oxidases (SSAOs). We investigated whether soluble VAP-1 (sVAP-1) displays SSAO activity and thereby accounts for increased monoamine oxidase activity in the serum of patients with liver diseases.

Details

Original languageEnglish
Pages (from-to)1096-103
Number of pages8
JournalGastroenterology
Volume119
Issue number4
Publication statusPublished - Oct 2000

Keywords

  • Amine Oxidase (Copper-Containing), Aspartate Aminotransferases, Bile, Bilirubin, Biological Markers, Carcinoma, Hepatocellular, Cell Adhesion Molecules, Chronic Disease, Colorectal Neoplasms, Creatinine, Enzyme-Linked Immunosorbent Assay, Hepatitis, Hepatitis, Alcoholic, Humans, Liver Circulation, Liver Cirrhosis, Alcoholic, Liver Diseases, Liver Failure, Acute, Liver Neoplasms, Liver Transplantation, Monoamine Oxidase, Portal System, Reference Values, Sialoglycoproteins