Circulating soluble adhesion molecules in systemic vasculitis

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Circulating soluble adhesion molecules in systemic vasculitis. / Pall, A. A.; Drayson, M.; Richards, N. T.; Michael, J.; Drayson, M.; Adu, D.

In: Nephrology Dialysis Transplantation, Vol. 9, No. 7, 01.01.1994, p. 770-774.

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Pall, A. A. ; Drayson, M. ; Richards, N. T. ; Michael, J. ; Drayson, M. ; Adu, D. / Circulating soluble adhesion molecules in systemic vasculitis. In: Nephrology Dialysis Transplantation. 1994 ; Vol. 9, No. 7. pp. 770-774.

Bibtex

@article{f8aa07c41acf48aab2c99a5ab6fe507b,
title = "Circulating soluble adhesion molecules in systemic vasculitis",
abstract = "The plasma levels of soluble intercellular adhesion molecule-1 (sICAM-1), E-selectin (sE-selectin), and vascular cell adhesion molecule-1 (sVCAM-1), might reflect endothelial activation and injury and would therefore be useful markers of disease activity in vasculitis. To investigate this we measured the levels of sICAM-1, sE-selectin, and sVCAM-1 by two-site ELISAs in the plasma of patients with (a) active vasculitis (n = 16), (b) vasculitis in remission (n = 15), (c) chronic renal failure (CRF) (n = 10), and (d) normal healthy controls (n = 10). Plasma sICAM-1 levels were significantly higher in patients with active vasculitis, 323 ng/ml (193–607) compared with patients with inactive vasculitis, 199 ng/ml (131–297); P = 0.0006 and healthy controls, 188 ng/ml (138–259); P =0.0002. Plasma sE-selectin levels were also significantly higher in the patients with active vasculitis, 45 ng/ml (15–65) compared with patients with inactive vasculitis, 25 ng7sol;ml (15–55); P=0.027 but not when compared with healthy controls, 35 ng/ml (20–55); P=0.16. There was no difference in plasma sVCAM-1 levels between patients with active vasculitis, OD 0.56 (0.45–0.85) and inactive disease, OD 0.58 (0.47–0.79) (P=0.12) or with healthy controls OD 0.49 (0.42–0.68) (P=0.48). There were no significant differences between the plasma levels of any of the soluble adhe sion molecules between patients with active vasculitis and patients with chronic failure. In patients with a vasculitis there was a significant correlation between sICAM-1 and plasma C-reactive protein (CRP) (r=0.60, P=<0.01) and plasma von Willebrand factor (vWF) (r=0.42, P<0.05). Likewise there was a cor relation between sE-selectin and CRP (r=0.45, P<0.02) but not with vWF. There was a significant correlation between sICAM-1 and sE-selectin (r=0.38, P<0.05), but not between sICAM-1 and sVCAM-1 or sE- selectin and sVCAM-1. No correlation was found between sVCAM-1 levels and CRP and vWF concentrations or between the levels of any of the soluble adhesion molecules and serum creatinine. Plasma levels of sICAM-i and of sE-selectin but not of sVCAM-1 reflect disease activity in vasculitis and may be markers of endothelial and or tissue injury in these disorders.",
keywords = "Adhesion molecules, Endothelium, Vasculitis",
author = "Pall, {A. A.} and M. Drayson and Richards, {N. T.} and J. Michael and M. Drayson and D. Adu",
year = "1994",
month = jan,
day = "1",
doi = "10.1093/oxfordjournals.ndt.a092977",
language = "English",
volume = "9",
pages = "770--774",
journal = "Nephrology, Dialysis, Transplantation",
issn = "0931-0509",
publisher = "Oxford University Press",
number = "7",

}

RIS

TY - JOUR

T1 - Circulating soluble adhesion molecules in systemic vasculitis

AU - Pall, A. A.

AU - Drayson, M.

AU - Richards, N. T.

AU - Michael, J.

AU - Drayson, M.

AU - Adu, D.

PY - 1994/1/1

Y1 - 1994/1/1

N2 - The plasma levels of soluble intercellular adhesion molecule-1 (sICAM-1), E-selectin (sE-selectin), and vascular cell adhesion molecule-1 (sVCAM-1), might reflect endothelial activation and injury and would therefore be useful markers of disease activity in vasculitis. To investigate this we measured the levels of sICAM-1, sE-selectin, and sVCAM-1 by two-site ELISAs in the plasma of patients with (a) active vasculitis (n = 16), (b) vasculitis in remission (n = 15), (c) chronic renal failure (CRF) (n = 10), and (d) normal healthy controls (n = 10). Plasma sICAM-1 levels were significantly higher in patients with active vasculitis, 323 ng/ml (193–607) compared with patients with inactive vasculitis, 199 ng/ml (131–297); P = 0.0006 and healthy controls, 188 ng/ml (138–259); P =0.0002. Plasma sE-selectin levels were also significantly higher in the patients with active vasculitis, 45 ng/ml (15–65) compared with patients with inactive vasculitis, 25 ng7sol;ml (15–55); P=0.027 but not when compared with healthy controls, 35 ng/ml (20–55); P=0.16. There was no difference in plasma sVCAM-1 levels between patients with active vasculitis, OD 0.56 (0.45–0.85) and inactive disease, OD 0.58 (0.47–0.79) (P=0.12) or with healthy controls OD 0.49 (0.42–0.68) (P=0.48). There were no significant differences between the plasma levels of any of the soluble adhe sion molecules between patients with active vasculitis and patients with chronic failure. In patients with a vasculitis there was a significant correlation between sICAM-1 and plasma C-reactive protein (CRP) (r=0.60, P=<0.01) and plasma von Willebrand factor (vWF) (r=0.42, P<0.05). Likewise there was a cor relation between sE-selectin and CRP (r=0.45, P<0.02) but not with vWF. There was a significant correlation between sICAM-1 and sE-selectin (r=0.38, P<0.05), but not between sICAM-1 and sVCAM-1 or sE- selectin and sVCAM-1. No correlation was found between sVCAM-1 levels and CRP and vWF concentrations or between the levels of any of the soluble adhesion molecules and serum creatinine. Plasma levels of sICAM-i and of sE-selectin but not of sVCAM-1 reflect disease activity in vasculitis and may be markers of endothelial and or tissue injury in these disorders.

AB - The plasma levels of soluble intercellular adhesion molecule-1 (sICAM-1), E-selectin (sE-selectin), and vascular cell adhesion molecule-1 (sVCAM-1), might reflect endothelial activation and injury and would therefore be useful markers of disease activity in vasculitis. To investigate this we measured the levels of sICAM-1, sE-selectin, and sVCAM-1 by two-site ELISAs in the plasma of patients with (a) active vasculitis (n = 16), (b) vasculitis in remission (n = 15), (c) chronic renal failure (CRF) (n = 10), and (d) normal healthy controls (n = 10). Plasma sICAM-1 levels were significantly higher in patients with active vasculitis, 323 ng/ml (193–607) compared with patients with inactive vasculitis, 199 ng/ml (131–297); P = 0.0006 and healthy controls, 188 ng/ml (138–259); P =0.0002. Plasma sE-selectin levels were also significantly higher in the patients with active vasculitis, 45 ng/ml (15–65) compared with patients with inactive vasculitis, 25 ng7sol;ml (15–55); P=0.027 but not when compared with healthy controls, 35 ng/ml (20–55); P=0.16. There was no difference in plasma sVCAM-1 levels between patients with active vasculitis, OD 0.56 (0.45–0.85) and inactive disease, OD 0.58 (0.47–0.79) (P=0.12) or with healthy controls OD 0.49 (0.42–0.68) (P=0.48). There were no significant differences between the plasma levels of any of the soluble adhe sion molecules between patients with active vasculitis and patients with chronic failure. In patients with a vasculitis there was a significant correlation between sICAM-1 and plasma C-reactive protein (CRP) (r=0.60, P=<0.01) and plasma von Willebrand factor (vWF) (r=0.42, P<0.05). Likewise there was a cor relation between sE-selectin and CRP (r=0.45, P<0.02) but not with vWF. There was a significant correlation between sICAM-1 and sE-selectin (r=0.38, P<0.05), but not between sICAM-1 and sVCAM-1 or sE- selectin and sVCAM-1. No correlation was found between sVCAM-1 levels and CRP and vWF concentrations or between the levels of any of the soluble adhesion molecules and serum creatinine. Plasma levels of sICAM-i and of sE-selectin but not of sVCAM-1 reflect disease activity in vasculitis and may be markers of endothelial and or tissue injury in these disorders.

KW - Adhesion molecules

KW - Endothelium

KW - Vasculitis

UR - http://www.scopus.com/inward/record.url?scp=0028247254&partnerID=8YFLogxK

U2 - 10.1093/oxfordjournals.ndt.a092977

DO - 10.1093/oxfordjournals.ndt.a092977

M3 - Article

C2 - 7526274

AN - SCOPUS:0028247254

VL - 9

SP - 770

EP - 774

JO - Nephrology, Dialysis, Transplantation

JF - Nephrology, Dialysis, Transplantation

SN - 0931-0509

IS - 7

ER -