Circulating progenitor cells in patients with atrial fibrillation and their relation with serum markers of inflammation and angiogenesis

Research output: Contribution to journalArticle

Authors

Colleges, School and Institutes

Abstract

The pathophysiological inter-relationships and underlying 'drivers' of a prothrombotic state in atrial fibrillation (AF) are complex but may include endothelial abnormalities. Circulating progenitor cells (CPCs) have been recently described as a cell population that may promote repair of endothelial damage. We hypothesised abnormalities in this cell population, alongside abnormal markers of endothelial damage/dysfunction (von Willebrand factor, soluble E-selectin), apoptosis (soluble Fas, soluble Fas ligand), angiogenesis (vascular endothelial growth factor) and inflammation (interleukin-6) in 135 consecutive AF patients (14 with lone AF), who were compared to 33 'disease controls' and 13 healthy controls. We also explored whether restoration of sinus rhythm would alter these indices. No significant differences in research indices were observed between AF and disease controls, apart from soluble Fas levels (p

Details

Original languageEnglish
Pages (from-to)327-334
Number of pages8
JournalThrombosis and Haemostasis
Volume104
Issue number2
Publication statusPublished - 1 Aug 2010

Keywords

  • inflammation, apoptosis, angiogenesis, Atrial fibrillation, progenitor cells