Circulating hormone and cytokine response to low-load resistance training with blood flow restriction in older men

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Circulating hormone and cytokine response to low-load resistance training with blood flow restriction in older men. / Patterson, Stephen D; Leggate, Melanie; Nimmo, Myra A; Ferguson, Richard A.

In: European Journal of Applied Physiology, Vol. 113, No. 3, 03.2013, p. 713-9.

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@article{2ed3948c71114428acd46a44dc89f75a,
title = "Circulating hormone and cytokine response to low-load resistance training with blood flow restriction in older men",
abstract = "It has been suggested that circulating hormones and cytokines are important in the adaptive response to low-load resistance training (LLRT) with blood flow restriction (BFR); however, their response following this type of training in older men is unclear. Seven healthy older men (age 71.0 ± 6.5 year, height 1.77 ± 0.05 m, body mass 80.0 ± 7.5 kg; mean ± SD) performed five sets of unilateral LLRT knee extensions (20 % 1-RM) of both limbs, with or without BFR in a counterbalanced order. For the BFR condition, a pressure cuff was applied on the upper thigh and inflated to ~110 mmHg. Venous blood samples were taken at rest and 30-, 60- and 120-min post-exercise and measured for plasma concentrations of growth hormone (GH), insulin-like growth factor 1 (IGF-1), vascular endothelial growth factor (VEGF), cortisol and interleukin-6 (IL-6). GH increased (P < 0.05) from rest to 30-min post-exercise and was greater (P < 0.05) during LLRT with BFR than without. VEGF was significantly (P < 0.05) elevated from resting levels at 30-, 60- and 120-min post-exercise following LLRT with BFR with no change seen following LLRT without BFR. IL-6 increased (P < 0.05) from 30- to 60-min post-exercise and remained elevated at 120-min post-exercise in both conditions. Cortisol and IGF-1 were unaffected following exercise. In conclusion, a single bout of LLRT with BFR increases the circulating concentrations of GH and VEGF in older men and may explain the skeletal muscle and peripheral vascular adaptations observed following training with BFR.",
keywords = "Aged, Constriction, Cytokines, Hormones, Human Growth Hormone, Humans, Hydrocortisone, Insulin-Like Growth Factor I, Knee Joint, Male, Muscle Contraction, Muscle, Skeletal, Regional Blood Flow, Resistance Training, Thigh, Vascular Endothelial Growth Factor A, Weight-Bearing",
author = "Patterson, {Stephen D} and Melanie Leggate and Nimmo, {Myra A} and Ferguson, {Richard A}",
year = "2013",
month = mar,
doi = "10.1007/s00421-012-2479-5",
language = "English",
volume = "113",
pages = "713--9",
journal = "European Journal of Applied Physiology",
issn = "1439-6319",
publisher = "Springer Verlag",
number = "3",

}

RIS

TY - JOUR

T1 - Circulating hormone and cytokine response to low-load resistance training with blood flow restriction in older men

AU - Patterson, Stephen D

AU - Leggate, Melanie

AU - Nimmo, Myra A

AU - Ferguson, Richard A

PY - 2013/3

Y1 - 2013/3

N2 - It has been suggested that circulating hormones and cytokines are important in the adaptive response to low-load resistance training (LLRT) with blood flow restriction (BFR); however, their response following this type of training in older men is unclear. Seven healthy older men (age 71.0 ± 6.5 year, height 1.77 ± 0.05 m, body mass 80.0 ± 7.5 kg; mean ± SD) performed five sets of unilateral LLRT knee extensions (20 % 1-RM) of both limbs, with or without BFR in a counterbalanced order. For the BFR condition, a pressure cuff was applied on the upper thigh and inflated to ~110 mmHg. Venous blood samples were taken at rest and 30-, 60- and 120-min post-exercise and measured for plasma concentrations of growth hormone (GH), insulin-like growth factor 1 (IGF-1), vascular endothelial growth factor (VEGF), cortisol and interleukin-6 (IL-6). GH increased (P < 0.05) from rest to 30-min post-exercise and was greater (P < 0.05) during LLRT with BFR than without. VEGF was significantly (P < 0.05) elevated from resting levels at 30-, 60- and 120-min post-exercise following LLRT with BFR with no change seen following LLRT without BFR. IL-6 increased (P < 0.05) from 30- to 60-min post-exercise and remained elevated at 120-min post-exercise in both conditions. Cortisol and IGF-1 were unaffected following exercise. In conclusion, a single bout of LLRT with BFR increases the circulating concentrations of GH and VEGF in older men and may explain the skeletal muscle and peripheral vascular adaptations observed following training with BFR.

AB - It has been suggested that circulating hormones and cytokines are important in the adaptive response to low-load resistance training (LLRT) with blood flow restriction (BFR); however, their response following this type of training in older men is unclear. Seven healthy older men (age 71.0 ± 6.5 year, height 1.77 ± 0.05 m, body mass 80.0 ± 7.5 kg; mean ± SD) performed five sets of unilateral LLRT knee extensions (20 % 1-RM) of both limbs, with or without BFR in a counterbalanced order. For the BFR condition, a pressure cuff was applied on the upper thigh and inflated to ~110 mmHg. Venous blood samples were taken at rest and 30-, 60- and 120-min post-exercise and measured for plasma concentrations of growth hormone (GH), insulin-like growth factor 1 (IGF-1), vascular endothelial growth factor (VEGF), cortisol and interleukin-6 (IL-6). GH increased (P < 0.05) from rest to 30-min post-exercise and was greater (P < 0.05) during LLRT with BFR than without. VEGF was significantly (P < 0.05) elevated from resting levels at 30-, 60- and 120-min post-exercise following LLRT with BFR with no change seen following LLRT without BFR. IL-6 increased (P < 0.05) from 30- to 60-min post-exercise and remained elevated at 120-min post-exercise in both conditions. Cortisol and IGF-1 were unaffected following exercise. In conclusion, a single bout of LLRT with BFR increases the circulating concentrations of GH and VEGF in older men and may explain the skeletal muscle and peripheral vascular adaptations observed following training with BFR.

KW - Aged

KW - Constriction

KW - Cytokines

KW - Hormones

KW - Human Growth Hormone

KW - Humans

KW - Hydrocortisone

KW - Insulin-Like Growth Factor I

KW - Knee Joint

KW - Male

KW - Muscle Contraction

KW - Muscle, Skeletal

KW - Regional Blood Flow

KW - Resistance Training

KW - Thigh

KW - Vascular Endothelial Growth Factor A

KW - Weight-Bearing

U2 - 10.1007/s00421-012-2479-5

DO - 10.1007/s00421-012-2479-5

M3 - Article

C2 - 22922803

VL - 113

SP - 713

EP - 719

JO - European Journal of Applied Physiology

JF - European Journal of Applied Physiology

SN - 1439-6319

IS - 3

ER -