Circulating endothelial cells in atrial fibrillation with and without acute cardiovascular disease

Research output: Contribution to journalArticle

Authors

  • Bethan Freestone
  • AY Chong
  • Sunil Nadar
  • KW Lee
  • Andrew Blann

Colleges, School and Institutes

Abstract

Normal adults have very few circulating endothelial cells (CECs) in their blood, but increased levels have been shown in association with conditions associated with endothelial damage such as myocardial infarction and stroke. As atrial fibrillation (AF) is associated with a hypercoagulable state and abnormalities of plasma indices of endothelial damage/dysfunction, we hypothesised that CECs would also be raised in this condition, and would correlate with these plasma markers. We measured CECs (by immunofluoresence) as an indicator of frank endothelial damage, alongside 3 plasma indices of endothelial perturbation: von Willebrand factor (vWf), soluble E-selectin and soluble thrombomodulin (sTM) (all ELISA) in 28 patients with chronic 'stable' AF, 63 patients with AF plus an acute cardiovascular or cerebrovascular event as positive controls, and 20 healthy subjects in sinus rhythm as negative controls. Chronic 'stable' AF patients had significantly higher levels of plasma vWf (p

Details

Original languageEnglish
Pages (from-to)702-6
Number of pages5
JournalThrombosis and Haemostasis
Volume94
Issue number4
Publication statusPublished - 1 Oct 2005