Circulating endothelial cells in acute ischaemic stroke

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Circulating endothelial cells in acute ischaemic stroke. / Nadar, SK; Lip, Gregory; Lee, KW; Blann, Andrew.

In: Thrombosis and Haemostasis, Vol. 94, No. 4, 01.10.2005, p. 707-12.

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Nadar, SK ; Lip, Gregory ; Lee, KW ; Blann, Andrew. / Circulating endothelial cells in acute ischaemic stroke. In: Thrombosis and Haemostasis. 2005 ; Vol. 94, No. 4. pp. 707-12.

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@article{3d5e2f237be646d188cf168d7e5c97c8,
title = "Circulating endothelial cells in acute ischaemic stroke",
abstract = "Increased numbers of CD146-bearing circulating endothelial cells (CECs) in the peripheral blood probably represent the most direct evidence of endothelial cell damage. As acute ischaemic strokes are associated with endothelial abnormalities, we hypothesised that these CECs are raised in acute stroke, and that they would correlate with the other indices of endothelial perturbation, i.e. plasma von Willebrand factor (vWf) and soluble E-selectin. We studied 29 hypertensive patients (19 male; mean age 63 years) who presented with an acute stroke and compared them with 30 high risk hypertensive patients (21 male; mean age 62 years) and 30 normotensive controls (16 male; mean age 58 years). CECs were estimated by CD146 immunobead capture, vWf and soluble E-selectin by ELISA. Patients with an acute ischaemic stroke had significantly higher numbers of CECs/ml of blood (p",
author = "SK Nadar and Gregory Lip and KW Lee and Andrew Blann",
year = "2005",
month = oct,
day = "1",
doi = "10.1160/TH05-04-0707",
language = "English",
volume = "94",
pages = "707--12",
journal = "Thrombosis and Haemostasis",
issn = "0340-6245",
publisher = "Schattauer",
number = "4",

}

RIS

TY - JOUR

T1 - Circulating endothelial cells in acute ischaemic stroke

AU - Nadar, SK

AU - Lip, Gregory

AU - Lee, KW

AU - Blann, Andrew

PY - 2005/10/1

Y1 - 2005/10/1

N2 - Increased numbers of CD146-bearing circulating endothelial cells (CECs) in the peripheral blood probably represent the most direct evidence of endothelial cell damage. As acute ischaemic strokes are associated with endothelial abnormalities, we hypothesised that these CECs are raised in acute stroke, and that they would correlate with the other indices of endothelial perturbation, i.e. plasma von Willebrand factor (vWf) and soluble E-selectin. We studied 29 hypertensive patients (19 male; mean age 63 years) who presented with an acute stroke and compared them with 30 high risk hypertensive patients (21 male; mean age 62 years) and 30 normotensive controls (16 male; mean age 58 years). CECs were estimated by CD146 immunobead capture, vWf and soluble E-selectin by ELISA. Patients with an acute ischaemic stroke had significantly higher numbers of CECs/ml of blood (p

AB - Increased numbers of CD146-bearing circulating endothelial cells (CECs) in the peripheral blood probably represent the most direct evidence of endothelial cell damage. As acute ischaemic strokes are associated with endothelial abnormalities, we hypothesised that these CECs are raised in acute stroke, and that they would correlate with the other indices of endothelial perturbation, i.e. plasma von Willebrand factor (vWf) and soluble E-selectin. We studied 29 hypertensive patients (19 male; mean age 63 years) who presented with an acute stroke and compared them with 30 high risk hypertensive patients (21 male; mean age 62 years) and 30 normotensive controls (16 male; mean age 58 years). CECs were estimated by CD146 immunobead capture, vWf and soluble E-selectin by ELISA. Patients with an acute ischaemic stroke had significantly higher numbers of CECs/ml of blood (p

U2 - 10.1160/TH05-04-0707

DO - 10.1160/TH05-04-0707

M3 - Article

C2 - 16270621

VL - 94

SP - 707

EP - 712

JO - Thrombosis and Haemostasis

JF - Thrombosis and Haemostasis

SN - 0340-6245

IS - 4

ER -