Circulating DBP level and prognosis in operated lung cancer: an exploration of pathophysiology.

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Circulating DBP level and prognosis in operated lung cancer: an exploration of pathophysiology. / Turner, Alice; McGowan, L; Millen, A; Rajesh, P; Webster, C; Langman, G; Rock, G; Tachibana, I; Tomlinson, Michael; Berditchevski, Fedor; Naidu, Babu.

In: The European respiratory journal, Vol. 41, No. 2, 03.05.2012, p. 410-416.

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Turner, Alice ; McGowan, L ; Millen, A ; Rajesh, P ; Webster, C ; Langman, G ; Rock, G ; Tachibana, I ; Tomlinson, Michael ; Berditchevski, Fedor ; Naidu, Babu. / Circulating DBP level and prognosis in operated lung cancer: an exploration of pathophysiology. In: The European respiratory journal. 2012 ; Vol. 41, No. 2. pp. 410-416.

Bibtex

@article{bac2e420e62d4fa29b72fd0668025017,
title = "Circulating DBP level and prognosis in operated lung cancer: an exploration of pathophysiology.",
abstract = "Vitamin D stimulates transcription of anti-angiogenic and apoptotic factors that may suppress tumours, whilst vitamin D binding protein (DBP) may be a biomarker in murine lung cancer models. We sought to ascertain if the vitamin D axis is altered in lung cancer or influences prognosis.148 lung cancer patients, 68 other intrathoracic cancer patients and 33 non-cancer controls were studied for up to 5 years. Circulating DBP and vitamin D levels were compared between groups and their effect on survival assessed by Cox regression analysis. Expression of DBP and vitamin D receptor (VDR) was examined in lung cancer cell lines and in normal and tumour lung tissue by Western blot and immunohistochemistry.Low serum DBP levels predicted lung cancer specific death (p=0.04), and DBP was poorly expressed in lung cancer cells on Western blot and immunohistochemistry. Vitamin D did not predict cancer survival, and VDR expression was variable in tumours.Preservation of serum DBP is a significant independent factor associated with better cancer outcome in operated lung cancer patients. Given the established role of DBP in macrophage activation and clearance of abnormal cells further study on its involvement in lung cancer is merited.",
author = "Alice Turner and L McGowan and A Millen and P Rajesh and C Webster and G Langman and G Rock and I Tachibana and Michael Tomlinson and Fedor Berditchevski and Babu Naidu",
year = "2012",
month = may,
day = "3",
doi = "10.1183/09031936.00002912",
language = "English",
volume = "41",
pages = "410--416",
journal = "The European respiratory journal",
issn = "0903-1936",
publisher = "European Respiratory Society",
number = "2",

}

RIS

TY - JOUR

T1 - Circulating DBP level and prognosis in operated lung cancer: an exploration of pathophysiology.

AU - Turner, Alice

AU - McGowan, L

AU - Millen, A

AU - Rajesh, P

AU - Webster, C

AU - Langman, G

AU - Rock, G

AU - Tachibana, I

AU - Tomlinson, Michael

AU - Berditchevski, Fedor

AU - Naidu, Babu

PY - 2012/5/3

Y1 - 2012/5/3

N2 - Vitamin D stimulates transcription of anti-angiogenic and apoptotic factors that may suppress tumours, whilst vitamin D binding protein (DBP) may be a biomarker in murine lung cancer models. We sought to ascertain if the vitamin D axis is altered in lung cancer or influences prognosis.148 lung cancer patients, 68 other intrathoracic cancer patients and 33 non-cancer controls were studied for up to 5 years. Circulating DBP and vitamin D levels were compared between groups and their effect on survival assessed by Cox regression analysis. Expression of DBP and vitamin D receptor (VDR) was examined in lung cancer cell lines and in normal and tumour lung tissue by Western blot and immunohistochemistry.Low serum DBP levels predicted lung cancer specific death (p=0.04), and DBP was poorly expressed in lung cancer cells on Western blot and immunohistochemistry. Vitamin D did not predict cancer survival, and VDR expression was variable in tumours.Preservation of serum DBP is a significant independent factor associated with better cancer outcome in operated lung cancer patients. Given the established role of DBP in macrophage activation and clearance of abnormal cells further study on its involvement in lung cancer is merited.

AB - Vitamin D stimulates transcription of anti-angiogenic and apoptotic factors that may suppress tumours, whilst vitamin D binding protein (DBP) may be a biomarker in murine lung cancer models. We sought to ascertain if the vitamin D axis is altered in lung cancer or influences prognosis.148 lung cancer patients, 68 other intrathoracic cancer patients and 33 non-cancer controls were studied for up to 5 years. Circulating DBP and vitamin D levels were compared between groups and their effect on survival assessed by Cox regression analysis. Expression of DBP and vitamin D receptor (VDR) was examined in lung cancer cell lines and in normal and tumour lung tissue by Western blot and immunohistochemistry.Low serum DBP levels predicted lung cancer specific death (p=0.04), and DBP was poorly expressed in lung cancer cells on Western blot and immunohistochemistry. Vitamin D did not predict cancer survival, and VDR expression was variable in tumours.Preservation of serum DBP is a significant independent factor associated with better cancer outcome in operated lung cancer patients. Given the established role of DBP in macrophage activation and clearance of abnormal cells further study on its involvement in lung cancer is merited.

U2 - 10.1183/09031936.00002912

DO - 10.1183/09031936.00002912

M3 - Article

C2 - 22556021

VL - 41

SP - 410

EP - 416

JO - The European respiratory journal

JF - The European respiratory journal

SN - 0903-1936

IS - 2

ER -