Circadian phenotype impacts the brain’s resting state functional connectivity, attentional performance and sleepiness

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Circadian phenotype impacts the brain’s resting state functional connectivity, attentional performance and sleepiness. / Facer-Childs, Elise; Machado de Campos, Brunno; Middleton, Benita; Skene, Debra; Bagshaw, Andrew.

In: Sleep, Vol. 42, No. 5, zsz033, 05.2019.

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@article{8b504032c670442b88c33f968db16409,
title = "Circadian phenotype impacts the brain{\textquoteright}s resting state functional connectivity, attentional performance and sleepiness",
abstract = "IntroductionFunctional connectivity (FC) of the human brain{\textquoteright}s intrinsically connected networks underpins cognitive functioning and disruptions of FC are associated with sleep and neurological disorders. However, there is limited research on the impact of circadian phenotype and time of day on FC.Study ObjectivesThe aim of this study was to investigate resting-state FC of the default mode network (DMN) in Early and Late circadian phenotypes over a socially constrained day.MethodsThirty-eight healthy individuals (14 male, 22.7 ± 4.2 years) categorized as Early (n = 16) or Late (n = 22) using the Munich ChronoType Questionnaire took part. Following a 2-week baseline of actigraphy coupled with saliva samples for melatonin and cortisol rhythms, participants underwent testing at 14:00 hours, 20:00 hours, and 08:00 hours the following morning. Testing consisted of resting-state functional magnetic resonance imaging (fMRI), a structural T1 scan, attentional cognitive performance tasks, and self-reported daytime sleepiness. Seed-based FC analysis from the medial prefrontal and posterior cingulate cortices of the DMN was performed, compared between groups and linked with behavioral data.ResultsFundamental differences in the DMN were observed between Early and Late circadian phenotypes. Resting-state FC of the DMN predicted individual differences in attention and subjective ratings of sleepiness.ConclusionDifferences in FC of the DMN may underlie the compromised attentional performance and increased sleepiness commonly associated with Late types when they conform to a societally constrained day that does not match their intrinsic circadian phenotype.",
keywords = "Resting-state functional magnetic resonance imaging (fMRI), attentional performance, circadian phenotype, circadian rhythms, default mode network, sleep, sleepiness",
author = "Elise Facer-Childs and {Machado de Campos}, Brunno and Benita Middleton and Debra Skene and Andrew Bagshaw",
note = "{\textcopyright} Sleep Research Society 2019. Published by Oxford University Press [on behalf of the Sleep Research Society].",
year = "2019",
month = may
doi = "10.1093/sleep/zsz033",
language = "English",
volume = "42",
journal = "Sleep",
issn = "0161-8105",
publisher = "American Academy of Sleep Medicine",
number = "5",

}

RIS

TY - JOUR

T1 - Circadian phenotype impacts the brain’s resting state functional connectivity, attentional performance and sleepiness

AU - Facer-Childs, Elise

AU - Machado de Campos, Brunno

AU - Middleton, Benita

AU - Skene, Debra

AU - Bagshaw, Andrew

N1 - © Sleep Research Society 2019. Published by Oxford University Press [on behalf of the Sleep Research Society].

PY - 2019/5

Y1 - 2019/5

N2 - IntroductionFunctional connectivity (FC) of the human brain’s intrinsically connected networks underpins cognitive functioning and disruptions of FC are associated with sleep and neurological disorders. However, there is limited research on the impact of circadian phenotype and time of day on FC.Study ObjectivesThe aim of this study was to investigate resting-state FC of the default mode network (DMN) in Early and Late circadian phenotypes over a socially constrained day.MethodsThirty-eight healthy individuals (14 male, 22.7 ± 4.2 years) categorized as Early (n = 16) or Late (n = 22) using the Munich ChronoType Questionnaire took part. Following a 2-week baseline of actigraphy coupled with saliva samples for melatonin and cortisol rhythms, participants underwent testing at 14:00 hours, 20:00 hours, and 08:00 hours the following morning. Testing consisted of resting-state functional magnetic resonance imaging (fMRI), a structural T1 scan, attentional cognitive performance tasks, and self-reported daytime sleepiness. Seed-based FC analysis from the medial prefrontal and posterior cingulate cortices of the DMN was performed, compared between groups and linked with behavioral data.ResultsFundamental differences in the DMN were observed between Early and Late circadian phenotypes. Resting-state FC of the DMN predicted individual differences in attention and subjective ratings of sleepiness.ConclusionDifferences in FC of the DMN may underlie the compromised attentional performance and increased sleepiness commonly associated with Late types when they conform to a societally constrained day that does not match their intrinsic circadian phenotype.

AB - IntroductionFunctional connectivity (FC) of the human brain’s intrinsically connected networks underpins cognitive functioning and disruptions of FC are associated with sleep and neurological disorders. However, there is limited research on the impact of circadian phenotype and time of day on FC.Study ObjectivesThe aim of this study was to investigate resting-state FC of the default mode network (DMN) in Early and Late circadian phenotypes over a socially constrained day.MethodsThirty-eight healthy individuals (14 male, 22.7 ± 4.2 years) categorized as Early (n = 16) or Late (n = 22) using the Munich ChronoType Questionnaire took part. Following a 2-week baseline of actigraphy coupled with saliva samples for melatonin and cortisol rhythms, participants underwent testing at 14:00 hours, 20:00 hours, and 08:00 hours the following morning. Testing consisted of resting-state functional magnetic resonance imaging (fMRI), a structural T1 scan, attentional cognitive performance tasks, and self-reported daytime sleepiness. Seed-based FC analysis from the medial prefrontal and posterior cingulate cortices of the DMN was performed, compared between groups and linked with behavioral data.ResultsFundamental differences in the DMN were observed between Early and Late circadian phenotypes. Resting-state FC of the DMN predicted individual differences in attention and subjective ratings of sleepiness.ConclusionDifferences in FC of the DMN may underlie the compromised attentional performance and increased sleepiness commonly associated with Late types when they conform to a societally constrained day that does not match their intrinsic circadian phenotype.

KW - Resting-state functional magnetic resonance imaging (fMRI)

KW - attentional performance

KW - circadian phenotype

KW - circadian rhythms

KW - default mode network

KW - sleep

KW - sleepiness

UR - http://www.scopus.com/inward/record.url?scp=85066846860&partnerID=8YFLogxK

U2 - 10.1093/sleep/zsz033

DO - 10.1093/sleep/zsz033

M3 - Article

C2 - 30763951

VL - 42

JO - Sleep

JF - Sleep

SN - 0161-8105

IS - 5

M1 - zsz033

ER -