Chronic stimulation of the peroneal nerve in rats upregulates the pro-opiomelanocortin gene in spinal motoneurones

Sharon Hughes, RA Shiner, Margaret Smith

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Continuous unilateral stimulation of the peroneal nerve in rats for 8 h per day for 2 or 7 days caused significant increases in POMC mRNA and beta -endorphin immunoreactivity in bath ipsilateral and contralateral motoneurones. Intermittent stimulation, for 10-min periods with 90-min rest periods, for 8 h per day for 2 days also caused upregulation of POMC mRNA. It is suggested that expression of POMC-derived peptides in motoneurones may be important for maintaining muscle contractile function. (C) 2000 Elsevier Science BN. All rights reserved.
Original languageEnglish
Pages (from-to)191-193
Number of pages3
JournalBrain Research
Volume887
Issue number1
DOIs
Publication statusPublished - 1 Dec 2000

Keywords

  • motoneuron
  • exercise
  • pro-opiomelanocortin
  • beta-endorphin
  • nerve stimulation

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