Chronic stimulation of the peroneal nerve in rats upregulates the pro-opiomelanocortin gene in spinal motoneurones

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Colleges, School and Institutes


Continuous unilateral stimulation of the peroneal nerve in rats for 8 h per day for 2 or 7 days caused significant increases in POMC mRNA and beta -endorphin immunoreactivity in bath ipsilateral and contralateral motoneurones. Intermittent stimulation, for 10-min periods with 90-min rest periods, for 8 h per day for 2 days also caused upregulation of POMC mRNA. It is suggested that expression of POMC-derived peptides in motoneurones may be important for maintaining muscle contractile function. (C) 2000 Elsevier Science BN. All rights reserved.


Original languageEnglish
Pages (from-to)191-193
Number of pages3
JournalBrain Research
Issue number1
Publication statusPublished - 1 Dec 2000


  • motoneuron, exercise, pro-opiomelanocortin, beta-endorphin, nerve stimulation