Chronic oral ascorbic acid therapy worsens skeletal muscle metabolism in patients with chronic heart failure

AK Nightingale, JG Crilley, NC Pegge, EA Boehm, C Mumford, DJ Taylor, P Styles, K Clarke, Michael Frenneaux

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

BACKGROUND: Chronic heart failure (CHF) is associated with abnormalities of skeletal muscle metabolism. This may be due to impaired oxygen delivery as a result of endothelial dysfunction. AIMS: We postulated that ascorbic acid would improve oxygen delivery to exercising muscle and improve skeletal muscle metabolism. METHODS: We studied skeletal muscle metabolism using (31)P magnetic resonance spectroscopy in 39 CHF patients. Endothelial function was assessed by changes in pulse wave velocity. Subjects were randomised to receive 4 g ascorbic acid daily for 4 weeks in a placebo-controlled double-blind study. RESULTS: Ascorbic acid significantly increased phosphocreatine utilization during exercise. In addition, glycolytic ATP synthesis increased in the ascorbic acid group (change in rate of ATP synthesis at 1 min -0.21+/-0.76 with placebo, 2.06+/-0.60 following ascorbic acid; p
Original languageEnglish
Pages (from-to)287-91
Number of pages5
JournalEuropean Journal of Heart Failure
Volume9
DOIs
Publication statusPublished - 1 Mar 2007

Keywords

  • magnetic resonance spectroscopy
  • ascorbic acid
  • endothelial function
  • chronic heart failure

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