Chromatin Structure Profiling Identifies Crucial Regulators of Tumor Maintenance

Research output: Contribution to journalShort surveypeer-review

Colleges, School and Institutes

Abstract

Cancer is primarily caused by mutations in genes encoding transcriptional regulators and signaling molecules. These mutations cooperate to deregulate the tight control over gene expression that is otherwise seen in normal cells. One consequence of this process is deregulated transcription factor (TF) activity. This forum article highlights novel strategies that use genome-wide chromatin structure profiling to identify the deregulated factors on which cancer cells depend, with the ultimate aim of targeting them.

Details

Original languageEnglish
Pages (from-to)157-160
Number of pages4
JournalTrends in Cancer
Volume1
Issue number3
Publication statusPublished - 1 Nov 2015

Keywords

  • cancer, chromatin structure profiling, open chromatin, regulators of cancer biology, transcription factors

ASJC Scopus subject areas