Chromatin regulation by RUNX1

Monika Lichtinger; Maarten Hoogenkamp; H Krysinska; R Ingram; Constanze Bonifer

doi:10.1016/j.bcmd.2010.02.009

Chromatin regulation by RUNX1

Monika Lichtinger, Maarten Hoogenkamp, H Krysinska, R Ingram, Constanze Bonifer

Cancer and Genomic Sciences

Research output: Contribution to journal › Article

17 Citations (Scopus)

Abstract

The transcription factor RUNX1 is essential for definitive hematopoiesis and is required for the expression of a number of important hematopoietic regulator genes. It was recently shown that RUNX1 acts within a narrow developmental window during which it cannot be replaced by other members of the RUNX transcription factor family. Studies of the molecular basis of this phenomenon revealed that RUNX1 is required for the opening of chromatin of important hematopoietic regulator genes and for the formation, but not the maintenance of stable transcription factor complexes on these genes. However, the chromatin opening activity of RUNX1 is context dependent, indicating that it cooperates with alternate transcription factors at different stages of hematopoietic development. This review summarizes recent results on the regulation of chromatin structure by RUNX1 in developing hematopoietic cells.

Original language	English
Pages (from-to)	287-90
Number of pages	4
Journal	Blood Cells, Molecules & Diseases
Volume	44
Issue number	4
DOIs	https://doi.org/10.1016/j.bcmd.2010.02.009
Publication status	Published - 15 Apr 2010

Keywords

chromatin regulation
RUNX1

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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10.1016/j.bcmd.2010.02.009

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title = "Chromatin regulation by RUNX1",

abstract = "The transcription factor RUNX1 is essential for definitive hematopoiesis and is required for the expression of a number of important hematopoietic regulator genes. It was recently shown that RUNX1 acts within a narrow developmental window during which it cannot be replaced by other members of the RUNX transcription factor family. Studies of the molecular basis of this phenomenon revealed that RUNX1 is required for the opening of chromatin of important hematopoietic regulator genes and for the formation, but not the maintenance of stable transcription factor complexes on these genes. However, the chromatin opening activity of RUNX1 is context dependent, indicating that it cooperates with alternate transcription factors at different stages of hematopoietic development. This review summarizes recent results on the regulation of chromatin structure by RUNX1 in developing hematopoietic cells.",

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AU - Lichtinger, Monika

AU - Hoogenkamp, Maarten

AU - Krysinska, H

AU - Ingram, R

AU - Bonifer, Constanze

PY - 2010/4/15

Y1 - 2010/4/15

N2 - The transcription factor RUNX1 is essential for definitive hematopoiesis and is required for the expression of a number of important hematopoietic regulator genes. It was recently shown that RUNX1 acts within a narrow developmental window during which it cannot be replaced by other members of the RUNX transcription factor family. Studies of the molecular basis of this phenomenon revealed that RUNX1 is required for the opening of chromatin of important hematopoietic regulator genes and for the formation, but not the maintenance of stable transcription factor complexes on these genes. However, the chromatin opening activity of RUNX1 is context dependent, indicating that it cooperates with alternate transcription factors at different stages of hematopoietic development. This review summarizes recent results on the regulation of chromatin structure by RUNX1 in developing hematopoietic cells.

AB - The transcription factor RUNX1 is essential for definitive hematopoiesis and is required for the expression of a number of important hematopoietic regulator genes. It was recently shown that RUNX1 acts within a narrow developmental window during which it cannot be replaced by other members of the RUNX transcription factor family. Studies of the molecular basis of this phenomenon revealed that RUNX1 is required for the opening of chromatin of important hematopoietic regulator genes and for the formation, but not the maintenance of stable transcription factor complexes on these genes. However, the chromatin opening activity of RUNX1 is context dependent, indicating that it cooperates with alternate transcription factors at different stages of hematopoietic development. This review summarizes recent results on the regulation of chromatin structure by RUNX1 in developing hematopoietic cells.

KW - chromatin regulation

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DO - 10.1016/j.bcmd.2010.02.009

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EP - 290

JO - Blood Cells, Molecules & Diseases

JF - Blood Cells, Molecules & Diseases

IS - 4

ER -

Chromatin regulation by RUNX1

Abstract

Keywords

ASJC Scopus subject areas

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