Chromatin programming by developmentally regulated transcription factors: lessons from the study of haematopoietic stem cell specification and differentiation

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@article{ed9e2d55ad9a4db58be32cad2f5d0829,
title = "Chromatin programming by developmentally regulated transcription factors: lessons from the study of haematopoietic stem cell specification and differentiation",
abstract = "Although the body plan of individuals is encoded in their genomes, each cell type expresses a different gene expression programme and therefore has access to only a subset of this information. Alterations to gene expression programmes are the underlying basis for the differentiation of multiple cell types and are driven by tissue-specific transcription factors (TFs) that interact with the epigenetic regulatory machinery to programme the chromatin landscape into transcriptionally active and inactive states. The haematopoietic system has long served as a paradigm for studying the molecular principles that regulate gene expression in development. In this review article, we summarize the current knowledge on the mechanism of action of TFs regulating haematopoietic stem cell specification and differentiation, and place this information into the context of general principles governing development.",
keywords = "chromatin, haematopoietic specification, transcription factors",
author = "Nadine Obier and Constanze Bonifer",
note = "{\textcopyright} 2016 Federation of European Biochemical Societies.",
year = "2016",
month = aug,
day = "18",
doi = "10.1002/1873-3468.12343",
language = "English",
journal = "FEBS Letters",
issn = "0014-5793",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Chromatin programming by developmentally regulated transcription factors

T2 - lessons from the study of haematopoietic stem cell specification and differentiation

AU - Obier, Nadine

AU - Bonifer, Constanze

N1 - © 2016 Federation of European Biochemical Societies.

PY - 2016/8/18

Y1 - 2016/8/18

N2 - Although the body plan of individuals is encoded in their genomes, each cell type expresses a different gene expression programme and therefore has access to only a subset of this information. Alterations to gene expression programmes are the underlying basis for the differentiation of multiple cell types and are driven by tissue-specific transcription factors (TFs) that interact with the epigenetic regulatory machinery to programme the chromatin landscape into transcriptionally active and inactive states. The haematopoietic system has long served as a paradigm for studying the molecular principles that regulate gene expression in development. In this review article, we summarize the current knowledge on the mechanism of action of TFs regulating haematopoietic stem cell specification and differentiation, and place this information into the context of general principles governing development.

AB - Although the body plan of individuals is encoded in their genomes, each cell type expresses a different gene expression programme and therefore has access to only a subset of this information. Alterations to gene expression programmes are the underlying basis for the differentiation of multiple cell types and are driven by tissue-specific transcription factors (TFs) that interact with the epigenetic regulatory machinery to programme the chromatin landscape into transcriptionally active and inactive states. The haematopoietic system has long served as a paradigm for studying the molecular principles that regulate gene expression in development. In this review article, we summarize the current knowledge on the mechanism of action of TFs regulating haematopoietic stem cell specification and differentiation, and place this information into the context of general principles governing development.

KW - chromatin

KW - haematopoietic specification

KW - transcription factors

U2 - 10.1002/1873-3468.12343

DO - 10.1002/1873-3468.12343

M3 - Article

C2 - 27497427

JO - FEBS Letters

JF - FEBS Letters

SN - 0014-5793

ER -