Cholinergically stimulated phosphatidylinositol breakdown in parotid gland fragments is independent of the ionic environment

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Carbamoylcholine stimulated phosphatidylinositol breakdown in rat parotid gland fragments incubated in either a Krebs Ringer medium or an ion depleted iso osmotic sucrose medium. This suggests that phosphatidylinositol breakdown is not initiated by a change in the intracellular concentration of Na+ or of K+, and previous experiments have already indicated that it is independent of cyclic nucleotides and Ca2+. Thus it seems that this reaction may be initiated by a direct interaction at the plasma membrane between the activated muscarinic cholinergic receptor system and the enzyme that catalyses phosphatidylinositol breakdown.


Original languageEnglish
Pages (from-to)505-507
Number of pages3
JournalBiochemical Journal
Issue number2
Publication statusPublished - 1 Jan 1976