Abstract
Chemokines are a family of structurally related proteins that share the ability to induce migration of specific subsets of leucocytes. These specialised cytokines play a critical part in the generation of cellular inflammation, both in the protective responses to invading pathogens and in the pathological processes associated with infection and immune-mediated diseases. Chemokines are more than simple chemotactic factors, since they are also implicated in leucocyte activation, angiogenesis, and antimicrobial functions, including a protective role in HIV infection. These molecules provide potentially valuable targets for therapeutic intervention in a wide range of diseases.
Original language | English |
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Pages (from-to) | 490-5 |
Number of pages | 6 |
Journal | Lancet |
Volume | 349 |
Issue number | 9050 |
Publication status | Published - 15 Feb 1997 |
Keywords
- Chemokines
- Chemotactic Factors
- Chemotaxis, Leukocyte
- Cytokines
- HIV Infections
- Humans
- Inflammation Mediators
- Leukocytes