Chemokines: leucocyte recruitment and activation cytokines

Research output: Contribution to journalArticlepeer-review

Authors

Abstract

Chemokines are a family of structurally related proteins that share the ability to induce migration of specific subsets of leucocytes. These specialised cytokines play a critical part in the generation of cellular inflammation, both in the protective responses to invading pathogens and in the pathological processes associated with infection and immune-mediated diseases. Chemokines are more than simple chemotactic factors, since they are also implicated in leucocyte activation, angiogenesis, and antimicrobial functions, including a protective role in HIV infection. These molecules provide potentially valuable targets for therapeutic intervention in a wide range of diseases.

Details

Original languageEnglish
Pages (from-to)490-5
Number of pages6
JournalLancet
Volume349
Issue number9050
Publication statusPublished - 15 Feb 1997

Keywords

  • Chemokines, Chemotactic Factors, Chemotaxis, Leukocyte, Cytokines, HIV Infections, Humans, Inflammation Mediators, Leukocytes

Sustainable Development Goals