Characterization of Nanoparticle Batch-To-Batch Variability
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Characterization of Nanoparticle Batch-To-Batch Variability. / Mülhopt, Sonja; Diabaté, Silvia; Dilger, Marco; Adelhelm, Christel; Anderlohr, Christopher; Bergfeldt, Thomas; Gómez de la Torre, Johan; Jiang, Yunhong; Valsami-Jones, Eugenia; Langevin, Dominique; Lynch, Iseult; Mahon, Eugene; Nelissen, Inge; Piella, Jordi; Puntes, Victor; Ray, Sikha; Schneider, Reinhard; Wilkins, Terry; Weiss, Carsten; Paur, Hanns-Rudolf.
In: Nanomaterials, Vol. 8, No. 5, 311, 08.05.2018.Research output: Contribution to journal › Article › peer-review
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TY - JOUR
T1 - Characterization of Nanoparticle Batch-To-Batch Variability
AU - Mülhopt, Sonja
AU - Diabaté, Silvia
AU - Dilger, Marco
AU - Adelhelm, Christel
AU - Anderlohr, Christopher
AU - Bergfeldt, Thomas
AU - Gómez de la Torre, Johan
AU - Jiang, Yunhong
AU - Valsami-Jones, Eugenia
AU - Langevin, Dominique
AU - Lynch, Iseult
AU - Mahon, Eugene
AU - Nelissen, Inge
AU - Piella, Jordi
AU - Puntes, Victor
AU - Ray, Sikha
AU - Schneider, Reinhard
AU - Wilkins, Terry
AU - Weiss, Carsten
AU - Paur, Hanns-Rudolf
PY - 2018/5/8
Y1 - 2018/5/8
N2 - A central challenge for the safe design of nanomaterials (NMs) is the inherent variability of NM properties, both as produced and as they interact with and evolve in, their surroundings. This has led to uncertainty in the literature regarding whether the biological and toxicological effects reported for NMs are related to specific NM properties themselves, or rather to the presence of impurities or physical effects such as agglomeration of particles. Thus, there is a strong need for systematic evaluation of the synthesis and processing parameters that lead to potential variability of different NM batches and the reproducible production of commonly utilized NMs. The work described here represents over three years of effort across 14 European laboratories to assess the reproducibility of nanoparticle properties produced by the same and modified synthesis routes for four of the OECD priority NMs (silica dioxide, zinc oxide, cerium dioxide and titanium dioxide) as well as amine-modified polystyrene NMs, which are frequently employed as positive controls for nanotoxicity studies. For 46 different batches of the selected NMs, all physicochemical descriptors as prioritized by the OECD have been fully characterized. The study represents the most complete assessment of NMs batch-to-batch variability performed to date and provides numerous important insights into the potential sources of variability of NMs and how these might be reduced.
AB - A central challenge for the safe design of nanomaterials (NMs) is the inherent variability of NM properties, both as produced and as they interact with and evolve in, their surroundings. This has led to uncertainty in the literature regarding whether the biological and toxicological effects reported for NMs are related to specific NM properties themselves, or rather to the presence of impurities or physical effects such as agglomeration of particles. Thus, there is a strong need for systematic evaluation of the synthesis and processing parameters that lead to potential variability of different NM batches and the reproducible production of commonly utilized NMs. The work described here represents over three years of effort across 14 European laboratories to assess the reproducibility of nanoparticle properties produced by the same and modified synthesis routes for four of the OECD priority NMs (silica dioxide, zinc oxide, cerium dioxide and titanium dioxide) as well as amine-modified polystyrene NMs, which are frequently employed as positive controls for nanotoxicity studies. For 46 different batches of the selected NMs, all physicochemical descriptors as prioritized by the OECD have been fully characterized. The study represents the most complete assessment of NMs batch-to-batch variability performed to date and provides numerous important insights into the potential sources of variability of NMs and how these might be reduced.
KW - nanosafety
KW - particle size
KW - impurities
KW - reactive oxygen species
U2 - 10.3390/nano8050311
DO - 10.3390/nano8050311
M3 - Article
C2 - 29738461
VL - 8
JO - Nanomaterials
JF - Nanomaterials
SN - 2079-4991
IS - 5
M1 - 311
ER -