Characterization of Nanoparticle Batch-To-Batch Variability

Research output: Contribution to journalArticle

Standard

Characterization of Nanoparticle Batch-To-Batch Variability. / Mülhopt, Sonja; Diabaté, Silvia; Dilger, Marco; Adelhelm, Christel; Anderlohr, Christopher; Bergfeldt, Thomas; Gómez de la Torre, Johan; Jiang, Yunhong; Valsami-Jones, Eugenia; Langevin, Dominique; Lynch, Iseult; Mahon, Eugene; Nelissen, Inge; Piella, Jordi; Puntes, Victor; Ray, Sikha; Schneider, Reinhard; Wilkins, Terry; Weiss, Carsten; Paur, Hanns-Rudolf.

In: Nanomaterials, Vol. 8, No. 5, 311, 08.05.2018.

Research output: Contribution to journalArticle

Harvard

Mülhopt, S, Diabaté, S, Dilger, M, Adelhelm, C, Anderlohr, C, Bergfeldt, T, Gómez de la Torre, J, Jiang, Y, Valsami-Jones, E, Langevin, D, Lynch, I, Mahon, E, Nelissen, I, Piella, J, Puntes, V, Ray, S, Schneider, R, Wilkins, T, Weiss, C & Paur, H-R 2018, 'Characterization of Nanoparticle Batch-To-Batch Variability', Nanomaterials, vol. 8, no. 5, 311. https://doi.org/10.3390/nano8050311

APA

Mülhopt, S., Diabaté, S., Dilger, M., Adelhelm, C., Anderlohr, C., Bergfeldt, T., Gómez de la Torre, J., Jiang, Y., Valsami-Jones, E., Langevin, D., Lynch, I., Mahon, E., Nelissen, I., Piella, J., Puntes, V., Ray, S., Schneider, R., Wilkins, T., Weiss, C., & Paur, H-R. (2018). Characterization of Nanoparticle Batch-To-Batch Variability. Nanomaterials, 8(5), [311]. https://doi.org/10.3390/nano8050311

Vancouver

Mülhopt S, Diabaté S, Dilger M, Adelhelm C, Anderlohr C, Bergfeldt T et al. Characterization of Nanoparticle Batch-To-Batch Variability. Nanomaterials. 2018 May 8;8(5). 311. https://doi.org/10.3390/nano8050311

Author

Mülhopt, Sonja ; Diabaté, Silvia ; Dilger, Marco ; Adelhelm, Christel ; Anderlohr, Christopher ; Bergfeldt, Thomas ; Gómez de la Torre, Johan ; Jiang, Yunhong ; Valsami-Jones, Eugenia ; Langevin, Dominique ; Lynch, Iseult ; Mahon, Eugene ; Nelissen, Inge ; Piella, Jordi ; Puntes, Victor ; Ray, Sikha ; Schneider, Reinhard ; Wilkins, Terry ; Weiss, Carsten ; Paur, Hanns-Rudolf. / Characterization of Nanoparticle Batch-To-Batch Variability. In: Nanomaterials. 2018 ; Vol. 8, No. 5.

Bibtex

@article{166043f261cc4ae1906d3f029c98eeb5,
title = "Characterization of Nanoparticle Batch-To-Batch Variability",
abstract = "A central challenge for the safe design of nanomaterials (NMs) is the inherent variability of NM properties, both as produced and as they interact with and evolve in, their surroundings. This has led to uncertainty in the literature regarding whether the biological and toxicological effects reported for NMs are related to specific NM properties themselves, or rather to the presence of impurities or physical effects such as agglomeration of particles. Thus, there is a strong need for systematic evaluation of the synthesis and processing parameters that lead to potential variability of different NM batches and the reproducible production of commonly utilized NMs. The work described here represents over three years of effort across 14 European laboratories to assess the reproducibility of nanoparticle properties produced by the same and modified synthesis routes for four of the OECD priority NMs (silica dioxide, zinc oxide, cerium dioxide and titanium dioxide) as well as amine-modified polystyrene NMs, which are frequently employed as positive controls for nanotoxicity studies. For 46 different batches of the selected NMs, all physicochemical descriptors as prioritized by the OECD have been fully characterized. The study represents the most complete assessment of NMs batch-to-batch variability performed to date and provides numerous important insights into the potential sources of variability of NMs and how these might be reduced.",
keywords = "nanosafety , particle size , impurities , reactive oxygen species",
author = "Sonja M{\"u}lhopt and Silvia Diabat{\'e} and Marco Dilger and Christel Adelhelm and Christopher Anderlohr and Thomas Bergfeldt and {G{\'o}mez de la Torre}, Johan and Yunhong Jiang and Eugenia Valsami-Jones and Dominique Langevin and Iseult Lynch and Eugene Mahon and Inge Nelissen and Jordi Piella and Victor Puntes and Sikha Ray and Reinhard Schneider and Terry Wilkins and Carsten Weiss and Hanns-Rudolf Paur",
year = "2018",
month = may,
day = "8",
doi = "10.3390/nano8050311",
language = "English",
volume = "8",
journal = "Nanomaterials",
issn = "2079-4991",
publisher = "MDPI",
number = "5",

}

RIS

TY - JOUR

T1 - Characterization of Nanoparticle Batch-To-Batch Variability

AU - Mülhopt, Sonja

AU - Diabaté, Silvia

AU - Dilger, Marco

AU - Adelhelm, Christel

AU - Anderlohr, Christopher

AU - Bergfeldt, Thomas

AU - Gómez de la Torre, Johan

AU - Jiang, Yunhong

AU - Valsami-Jones, Eugenia

AU - Langevin, Dominique

AU - Lynch, Iseult

AU - Mahon, Eugene

AU - Nelissen, Inge

AU - Piella, Jordi

AU - Puntes, Victor

AU - Ray, Sikha

AU - Schneider, Reinhard

AU - Wilkins, Terry

AU - Weiss, Carsten

AU - Paur, Hanns-Rudolf

PY - 2018/5/8

Y1 - 2018/5/8

N2 - A central challenge for the safe design of nanomaterials (NMs) is the inherent variability of NM properties, both as produced and as they interact with and evolve in, their surroundings. This has led to uncertainty in the literature regarding whether the biological and toxicological effects reported for NMs are related to specific NM properties themselves, or rather to the presence of impurities or physical effects such as agglomeration of particles. Thus, there is a strong need for systematic evaluation of the synthesis and processing parameters that lead to potential variability of different NM batches and the reproducible production of commonly utilized NMs. The work described here represents over three years of effort across 14 European laboratories to assess the reproducibility of nanoparticle properties produced by the same and modified synthesis routes for four of the OECD priority NMs (silica dioxide, zinc oxide, cerium dioxide and titanium dioxide) as well as amine-modified polystyrene NMs, which are frequently employed as positive controls for nanotoxicity studies. For 46 different batches of the selected NMs, all physicochemical descriptors as prioritized by the OECD have been fully characterized. The study represents the most complete assessment of NMs batch-to-batch variability performed to date and provides numerous important insights into the potential sources of variability of NMs and how these might be reduced.

AB - A central challenge for the safe design of nanomaterials (NMs) is the inherent variability of NM properties, both as produced and as they interact with and evolve in, their surroundings. This has led to uncertainty in the literature regarding whether the biological and toxicological effects reported for NMs are related to specific NM properties themselves, or rather to the presence of impurities or physical effects such as agglomeration of particles. Thus, there is a strong need for systematic evaluation of the synthesis and processing parameters that lead to potential variability of different NM batches and the reproducible production of commonly utilized NMs. The work described here represents over three years of effort across 14 European laboratories to assess the reproducibility of nanoparticle properties produced by the same and modified synthesis routes for four of the OECD priority NMs (silica dioxide, zinc oxide, cerium dioxide and titanium dioxide) as well as amine-modified polystyrene NMs, which are frequently employed as positive controls for nanotoxicity studies. For 46 different batches of the selected NMs, all physicochemical descriptors as prioritized by the OECD have been fully characterized. The study represents the most complete assessment of NMs batch-to-batch variability performed to date and provides numerous important insights into the potential sources of variability of NMs and how these might be reduced.

KW - nanosafety

KW - particle size

KW - impurities

KW - reactive oxygen species

U2 - 10.3390/nano8050311

DO - 10.3390/nano8050311

M3 - Article

C2 - 29738461

VL - 8

JO - Nanomaterials

JF - Nanomaterials

SN - 2079-4991

IS - 5

M1 - 311

ER -