Changes in muscle size and MHC composition in response to resistance exercise with heavy and light loading intensity

Research output: Contribution to journalArticlepeer-review

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Changes in muscle size and MHC composition in response to resistance exercise with heavy and light loading intensity. / Holm, Lars; Reitelseder, Søren; Pedersen, T.G.; Doessing, Simon; Petersen, S.G.; Flyvbjerg, Allan; Andersen, J.L.; Aagaard, Per; Kjær, Michael.

In: Journal of Applied Physiology, Vol. 105, No. 5, 01.11.2008, p. 1454-1461.

Research output: Contribution to journalArticlepeer-review

Harvard

Holm, L, Reitelseder, S, Pedersen, TG, Doessing, S, Petersen, SG, Flyvbjerg, A, Andersen, JL, Aagaard, P & Kjær, M 2008, 'Changes in muscle size and MHC composition in response to resistance exercise with heavy and light loading intensity', Journal of Applied Physiology, vol. 105, no. 5, pp. 1454-1461. https://doi.org/10.1152/japplphysiol.90538.2008

APA

Holm, L., Reitelseder, S., Pedersen, T. G., Doessing, S., Petersen, S. G., Flyvbjerg, A., Andersen, J. L., Aagaard, P., & Kjær, M. (2008). Changes in muscle size and MHC composition in response to resistance exercise with heavy and light loading intensity. Journal of Applied Physiology, 105(5), 1454-1461. https://doi.org/10.1152/japplphysiol.90538.2008

Vancouver

Author

Holm, Lars ; Reitelseder, Søren ; Pedersen, T.G. ; Doessing, Simon ; Petersen, S.G. ; Flyvbjerg, Allan ; Andersen, J.L. ; Aagaard, Per ; Kjær, Michael. / Changes in muscle size and MHC composition in response to resistance exercise with heavy and light loading intensity. In: Journal of Applied Physiology. 2008 ; Vol. 105, No. 5. pp. 1454-1461.

Bibtex

@article{6e204920072448269e9cb2f2c6c75ec3,
title = "Changes in muscle size and MHC composition in response to resistance exercise with heavy and light loading intensity",
abstract = "Muscle mass accretion is accomplished by heavy-load resistance training. The effect of light-load resistance exercise has been far more sparsely investigated with regard to potential effect on muscle size and contractile strength. We applied a resistance exercise protocol in which the same individual trained one leg at 70% of one-repetition maximum (1RM) (heavy load, HL) while training the other leg at 15.5% 1RM (light load, LL). Eleven sedentary men (age 25 +/- 1 yr) trained for 12 wk at three times/week. Before and after the intervention muscle hypertrophy was determined by magnetic resonance imaging, muscle biopsies were obtained bilaterally from vastus lateralis for determination of myosin heavy chain (MHC) composition, and maximal muscle strength was assessed by 1RM testing and in an isokinetic dynamometer at 60 degrees /s. Quadriceps muscle cross-sectional area increased (P <0.05) 8 +/- 1% and 3 +/- 1% in HL and LL legs, respectively, with a greater gain in HL than LL (P <0.05). Likewise, 1RM strength increased (P <0.001) in both legs (HL: 36 +/- 5%, LL: 19 +/- 2%), albeit more so with HL (P <0.01). Isokinetic 60 degrees /s muscle strength improved by 13 +/- 5% (P <0.05) in HL but remained unchanged in LL (4 +/- 5%, not significant). Finally, MHC IIX protein expression was decreased with HL but not LL, despite identical total workload in HL and LL. Our main finding was that LL resistance training was sufficient to induce a small but significant muscle hypertrophy in healthy young men. However, LL resistance training was inferior to HL training in evoking adaptive changes in muscle size and contractile strength and was insufficient to induce changes in MHC composition.",
author = "Lars Holm and S{\o}ren Reitelseder and T.G. Pedersen and Simon Doessing and S.G. Petersen and Allan Flyvbjerg and J.L. Andersen and Per Aagaard and Michael Kj{\ae}r",
year = "2008",
month = nov,
day = "1",
doi = "10.1152/japplphysiol.90538.2008",
language = "English",
volume = "105",
pages = "1454--1461",
journal = "Journal of Applied Physiology",
issn = "8750-7587",
publisher = "American Physiological Society",
number = "5",

}

RIS

TY - JOUR

T1 - Changes in muscle size and MHC composition in response to resistance exercise with heavy and light loading intensity

AU - Holm, Lars

AU - Reitelseder, Søren

AU - Pedersen, T.G.

AU - Doessing, Simon

AU - Petersen, S.G.

AU - Flyvbjerg, Allan

AU - Andersen, J.L.

AU - Aagaard, Per

AU - Kjær, Michael

PY - 2008/11/1

Y1 - 2008/11/1

N2 - Muscle mass accretion is accomplished by heavy-load resistance training. The effect of light-load resistance exercise has been far more sparsely investigated with regard to potential effect on muscle size and contractile strength. We applied a resistance exercise protocol in which the same individual trained one leg at 70% of one-repetition maximum (1RM) (heavy load, HL) while training the other leg at 15.5% 1RM (light load, LL). Eleven sedentary men (age 25 +/- 1 yr) trained for 12 wk at three times/week. Before and after the intervention muscle hypertrophy was determined by magnetic resonance imaging, muscle biopsies were obtained bilaterally from vastus lateralis for determination of myosin heavy chain (MHC) composition, and maximal muscle strength was assessed by 1RM testing and in an isokinetic dynamometer at 60 degrees /s. Quadriceps muscle cross-sectional area increased (P <0.05) 8 +/- 1% and 3 +/- 1% in HL and LL legs, respectively, with a greater gain in HL than LL (P <0.05). Likewise, 1RM strength increased (P <0.001) in both legs (HL: 36 +/- 5%, LL: 19 +/- 2%), albeit more so with HL (P <0.01). Isokinetic 60 degrees /s muscle strength improved by 13 +/- 5% (P <0.05) in HL but remained unchanged in LL (4 +/- 5%, not significant). Finally, MHC IIX protein expression was decreased with HL but not LL, despite identical total workload in HL and LL. Our main finding was that LL resistance training was sufficient to induce a small but significant muscle hypertrophy in healthy young men. However, LL resistance training was inferior to HL training in evoking adaptive changes in muscle size and contractile strength and was insufficient to induce changes in MHC composition.

AB - Muscle mass accretion is accomplished by heavy-load resistance training. The effect of light-load resistance exercise has been far more sparsely investigated with regard to potential effect on muscle size and contractile strength. We applied a resistance exercise protocol in which the same individual trained one leg at 70% of one-repetition maximum (1RM) (heavy load, HL) while training the other leg at 15.5% 1RM (light load, LL). Eleven sedentary men (age 25 +/- 1 yr) trained for 12 wk at three times/week. Before and after the intervention muscle hypertrophy was determined by magnetic resonance imaging, muscle biopsies were obtained bilaterally from vastus lateralis for determination of myosin heavy chain (MHC) composition, and maximal muscle strength was assessed by 1RM testing and in an isokinetic dynamometer at 60 degrees /s. Quadriceps muscle cross-sectional area increased (P <0.05) 8 +/- 1% and 3 +/- 1% in HL and LL legs, respectively, with a greater gain in HL than LL (P <0.05). Likewise, 1RM strength increased (P <0.001) in both legs (HL: 36 +/- 5%, LL: 19 +/- 2%), albeit more so with HL (P <0.01). Isokinetic 60 degrees /s muscle strength improved by 13 +/- 5% (P <0.05) in HL but remained unchanged in LL (4 +/- 5%, not significant). Finally, MHC IIX protein expression was decreased with HL but not LL, despite identical total workload in HL and LL. Our main finding was that LL resistance training was sufficient to induce a small but significant muscle hypertrophy in healthy young men. However, LL resistance training was inferior to HL training in evoking adaptive changes in muscle size and contractile strength and was insufficient to induce changes in MHC composition.

U2 - 10.1152/japplphysiol.90538.2008

DO - 10.1152/japplphysiol.90538.2008

M3 - Article

VL - 105

SP - 1454

EP - 1461

JO - Journal of Applied Physiology

JF - Journal of Applied Physiology

SN - 8750-7587

IS - 5

ER -