Changes in cortical dopamine D1 receptor binding associated with cognitive training

Fiona McNab; Andrea Varrone; Lars Farde; Aurelija Jucaite; Paulina Bystritsky; Hans Forssberg; Torkel Klingberg

doi:10.1126/science.1166102

Changes in cortical dopamine D1 receptor binding associated with cognitive training

Fiona McNab, Andrea Varrone, Lars Farde, Aurelija Jucaite, Paulina Bystritsky, Hans Forssberg, Torkel Klingberg

Psychology

Research output: Contribution to journal › Article › peer-review

366 Citations (Scopus)

Abstract

Working memory is a key function for human cognition, dependent on adequate dopamine neurotransmission. Here we show that the training of working memory, which improves working memory capacity, is associated with changes in the density of cortical dopamine D1 receptors. Fourteen hours of training over 5 weeks was associated with changes in both prefrontal and parietal D1 binding potential. This plasticity of the dopamine D1 receptor system demonstrates a reciprocal interplay between mental activity and brain biochemistry in vivo.

Original language	English
Pages (from-to)	800-2
Number of pages	3
Journal	Science
Volume	323
Issue number	5915
DOIs	https://doi.org/10.1126/science.1166102
Publication status	Published - 6 Feb 2009

Keywords

Adult
Brain Mapping
Cerebral Cortex
Cognition
Dopamine
Humans
Magnetic Resonance Imaging
Male
Memory, Short-Term
Parietal Lobe
Prefrontal Cortex
Receptors, Dopamine D1
Receptors, Dopamine D2
Regression Analysis
Synaptic Transmission
Young Adult

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10.1126/science.1166102

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abstract = "Working memory is a key function for human cognition, dependent on adequate dopamine neurotransmission. Here we show that the training of working memory, which improves working memory capacity, is associated with changes in the density of cortical dopamine D1 receptors. Fourteen hours of training over 5 weeks was associated with changes in both prefrontal and parietal D1 binding potential. This plasticity of the dopamine D1 receptor system demonstrates a reciprocal interplay between mental activity and brain biochemistry in vivo.",

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AU - McNab, Fiona

AU - Varrone, Andrea

AU - Farde, Lars

AU - Jucaite, Aurelija

AU - Bystritsky, Paulina

AU - Forssberg, Hans

AU - Klingberg, Torkel

PY - 2009/2/6

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N2 - Working memory is a key function for human cognition, dependent on adequate dopamine neurotransmission. Here we show that the training of working memory, which improves working memory capacity, is associated with changes in the density of cortical dopamine D1 receptors. Fourteen hours of training over 5 weeks was associated with changes in both prefrontal and parietal D1 binding potential. This plasticity of the dopamine D1 receptor system demonstrates a reciprocal interplay between mental activity and brain biochemistry in vivo.

AB - Working memory is a key function for human cognition, dependent on adequate dopamine neurotransmission. Here we show that the training of working memory, which improves working memory capacity, is associated with changes in the density of cortical dopamine D1 receptors. Fourteen hours of training over 5 weeks was associated with changes in both prefrontal and parietal D1 binding potential. This plasticity of the dopamine D1 receptor system demonstrates a reciprocal interplay between mental activity and brain biochemistry in vivo.

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KW - Dopamine

KW - Humans

KW - Magnetic Resonance Imaging

KW - Male

KW - Memory, Short-Term

KW - Parietal Lobe

KW - Prefrontal Cortex

KW - Receptors, Dopamine D1

KW - Receptors, Dopamine D2

KW - Regression Analysis

KW - Synaptic Transmission

KW - Young Adult

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VL - 323

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EP - 802

JO - Science

JF - Science

IS - 5915

ER -

Changes in cortical dopamine D1 receptor binding associated with cognitive training

Abstract

Keywords

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