Challenges to curing primary brain tumours

Research output: Contribution to journalReview articlepeer-review


  • Kenneth Aldape
  • Kevin M Brindle
  • Louis Chesler
  • Rajesh Chopra
  • Amar Gajjar
  • Mark R Gilbert
  • Nicholas Gottardo
  • David H Gutmann
  • Darren Hargrave
  • Eric C Holland
  • David T W Jones
  • Johanna A Joyce
  • Mark W Kieran
  • Ingo K Mellinghoff
  • Melinda Merchant
  • Stefan M Pfister
  • Steven M Pollard
  • Vijay Ramaswamy
  • Jeremy N Rich
  • Giles W Robinson
  • David H Rowitch
  • John H Sampson
  • Michael D Taylor
  • Paul Workman
  • Richard J Gilbertson

Colleges, School and Institutes

External organisations

  • University of Toronto
  • University of Cambridge
  • The Institute of Cancer Research
  • Department of Oncology, St Jude Children's Research Hospital, Memphis, TN, USA.
  • Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.
  • University of Western Australia
  • Great Ormond Street Hospital for Children, London, UK.
  • Fred Hutchinson Cancer Research Center
  • Pediatric Glioma Research Group, Hopp Children's Cancer Center at the NCT Heidelberg, Heidelberg, Germany.
  • University of Lausanne
  • Harvard Medical School
  • Memorial Sloan Kettering Cancer Center
  • AstraZeneca
  • Division of Pediatric Oncology, Hopp Children's Cancer Center at the NCT Heidelberg, Heidelberg, Germany.
  • University of Edinburgh
  • Department of Paediatrics, The Hospital for Sick Children, Toronto, Ontario, Canada.
  • University of California, San Diego
  • The Preston Robert Tisch Brain Tumor Center, Duke Cancer Center, Durham, NC, USA.
  • The Arthur and Sonia Labatt Brain Tumour Research Centre and Division of Neurosurgery, The Hospital for Sick Children, Toronto, Ontario, Canada.
  • Washington University


Despite decades of research, brain tumours remain among the deadliest of all forms of cancer. The ability of these tumours to resist almost all conventional and novel treatments relates, in part, to the unique cell-intrinsic and microenvironmental properties of neural tissues. In an attempt to encourage progress in our understanding and ability to successfully treat patients with brain tumours, Cancer Research UK convened an international panel of clinicians and laboratory-based scientists to identify challenges that must be overcome if we are to cure all patients with a brain tumour. The seven key challenges summarized in this Position Paper are intended to serve as foci for future research and investment.


Original languageEnglish
Pages (from-to)509-520
Number of pages12
JournalNature Reviews Clinical Oncology
Early online date7 Feb 2019
Publication statusE-pub ahead of print - 7 Feb 2019

ASJC Scopus subject areas

Sustainable Development Goals