Challenges in evaluating surgical innovation

Patrick L Ergina; Jonathan A Cook; Jane M Blazeby; Isabelle Boutron; Pierre-Alain Clavien; Barnaby C Reeves; Christoph M Seiler; Douglas G Altman; Jeffrey K Aronson; Jeffrey S Barkun; W Bruce Campbell; Jonathan A Cook; Liane S Feldman; David R Flum; Paul Glasziou; Guy J Maddern; John C Marshall; Peter McCulloch; Jon Nicholl; Steven M Strasberg; Jonathan L Meakins; Deborah Ashby; Nick Black; John Bunker; Martin Burton; Marion Campbell; Kalipso Chalkidou; Iain Chalmers; Marc de Leval; Jon Deeks; Adrian Grant; Muir Gray; Roger Greenhalgh; Milos Jenicek; Sean Kehoe; Richard Lilford; Peter Littlejohns; Yoon Loke; Rajan Madhock; Kim McPherson; Peter Rothwell; Bill Summerskill; David Taggart; Parris Tekkis; Matthew Thompson; Tom Treasure; Ulrich Trohler; Jan Vandenbroucke; Balliol Collaboration

doi:10.1016/S0140-6736(09)61086-2

Challenges in evaluating surgical innovation

Patrick L Ergina, Jonathan A Cook, Jane M Blazeby, Isabelle Boutron, Pierre-Alain Clavien, Barnaby C Reeves, Christoph M Seiler, Douglas G Altman, Jeffrey K Aronson, Jeffrey S Barkun, W Bruce Campbell, Jonathan A Cook, Liane S Feldman, David R Flum, Paul Glasziou, Guy J Maddern, John C Marshall, Peter McCulloch, Jon Nicholl, Steven M StrasbergJonathan L Meakins, Deborah Ashby, Nick Black, John Bunker, Martin Burton, Marion Campbell, Kalipso Chalkidou, Iain Chalmers, Marc de Leval, Jon Deeks, Adrian Grant, Muir Gray, Roger Greenhalgh, Milos Jenicek, Sean Kehoe, Richard Lilford, Peter Littlejohns, Yoon Loke, Rajan Madhock, Kim McPherson, Peter Rothwell, Bill Summerskill, David Taggart, Parris Tekkis, Matthew Thompson, Tom Treasure, Ulrich Trohler, Jan Vandenbroucke, Balliol Collaboration

Research output: Contribution to journal › Article › peer-review

394 Citations (Scopus)

Abstract

Research on surgical interventions is associated with several methodological and practical challenges of which few, if any, apply only to surgery. However, surgical evaluation is especially demanding because many of these challenges coincide. In this report, the second of three on surgical innovation and evaluation, we discuss obstacles related to the study design of randomised controlled trials and non-randomised studies assessing surgical interventions. We also describe the issues related to the nature of surgical procedures-for example, their complexity, surgeon-related factors, and the range of outcomes. Although difficult, surgical evaluation is achievable and necessary. Solutions tailored to surgical research and a framework for generating evidence on which to base surgical practice are essential.

Original language	English
Pages (from-to)	1097-104
Number of pages	8
Journal	Lancet
Volume	374
Issue number	9695
DOIs	https://doi.org/10.1016/S0140-6736(09)61086-2
Publication status	Published - 26 Sept 2009

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Ergina, P. L., Cook, J. A., Blazeby, J. M., Boutron, I., Clavien, P-A., Reeves, B. C., Seiler, C. M., Altman, D. G., Aronson, J. K., Barkun, J. S., Campbell, W. B., Cook, J. A., Feldman, L. S., Flum, D. R., Glasziou, P., Maddern, G. J., Marshall, J. C., McCulloch, P., Nicholl, J., ... Balliol Collaboration (2009). Challenges in evaluating surgical innovation. Lancet, 374(9695), 1097-104. https://doi.org/10.1016/S0140-6736(09)61086-2

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abstract = "Research on surgical interventions is associated with several methodological and practical challenges of which few, if any, apply only to surgery. However, surgical evaluation is especially demanding because many of these challenges coincide. In this report, the second of three on surgical innovation and evaluation, we discuss obstacles related to the study design of randomised controlled trials and non-randomised studies assessing surgical interventions. We also describe the issues related to the nature of surgical procedures-for example, their complexity, surgeon-related factors, and the range of outcomes. Although difficult, surgical evaluation is achievable and necessary. Solutions tailored to surgical research and a framework for generating evidence on which to base surgical practice are essential.",

author = "Ergina, {Patrick L} and Cook, {Jonathan A} and Blazeby, {Jane M} and Isabelle Boutron and Pierre-Alain Clavien and Reeves, {Barnaby C} and Seiler, {Christoph M} and Altman, {Douglas G} and Aronson, {Jeffrey K} and Barkun, {Jeffrey S} and Campbell, {W Bruce} and Cook, {Jonathan A} and Feldman, {Liane S} and Flum, {David R} and Paul Glasziou and Maddern, {Guy J} and Marshall, {John C} and Peter McCulloch and Jon Nicholl and Strasberg, {Steven M} and Meakins, {Jonathan L} and Deborah Ashby and Nick Black and John Bunker and Martin Burton and Marion Campbell and Kalipso Chalkidou and Iain Chalmers and {de Leval}, Marc and Jon Deeks and Adrian Grant and Muir Gray and Roger Greenhalgh and Milos Jenicek and Sean Kehoe and Richard Lilford and Peter Littlejohns and Yoon Loke and Rajan Madhock and Kim McPherson and Peter Rothwell and Bill Summerskill and David Taggart and Parris Tekkis and Matthew Thompson and Tom Treasure and Ulrich Trohler and Jan Vandenbroucke and {Balliol Collaboration}",

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Ergina, PL, Cook, JA, Blazeby, JM, Boutron, I, Clavien, P-A, Reeves, BC, Seiler, CM, Altman, DG, Aronson, JK, Barkun, JS, Campbell, WB, Cook, JA, Feldman, LS, Flum, DR, Glasziou, P, Maddern, GJ, Marshall, JC, McCulloch, P, Nicholl, J, Strasberg, SM, Meakins, JL, Ashby, D, Black, N, Bunker, J, Burton, M, Campbell, M, Chalkidou, K, Chalmers, I, de Leval, M, Deeks, J, Grant, A, Gray, M, Greenhalgh, R, Jenicek, M, Kehoe, S, Lilford, R, Littlejohns, P, Loke, Y, Madhock, R, McPherson, K, Rothwell, P, Summerskill, B, Taggart, D, Tekkis, P, Thompson, M, Treasure, T, Trohler, U, Vandenbroucke, J & Balliol Collaboration 2009, 'Challenges in evaluating surgical innovation', Lancet, vol. 374, no. 9695, pp. 1097-104. https://doi.org/10.1016/S0140-6736(09)61086-2

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AU - Ergina, Patrick L

AU - Cook, Jonathan A

AU - Blazeby, Jane M

AU - Boutron, Isabelle

AU - Clavien, Pierre-Alain

AU - Reeves, Barnaby C

AU - Seiler, Christoph M

AU - Altman, Douglas G

AU - Aronson, Jeffrey K

AU - Barkun, Jeffrey S

AU - Campbell, W Bruce

AU - Cook, Jonathan A

AU - Feldman, Liane S

AU - Flum, David R

AU - Glasziou, Paul

AU - Maddern, Guy J

AU - Marshall, John C

AU - McCulloch, Peter

AU - Nicholl, Jon

AU - Strasberg, Steven M

AU - Meakins, Jonathan L

AU - Ashby, Deborah

AU - Black, Nick

AU - Bunker, John

AU - Burton, Martin

AU - Campbell, Marion

AU - Chalkidou, Kalipso

AU - Chalmers, Iain

AU - de Leval, Marc

AU - Deeks, Jon

AU - Grant, Adrian

AU - Gray, Muir

AU - Greenhalgh, Roger

AU - Jenicek, Milos

AU - Kehoe, Sean

AU - Lilford, Richard

AU - Littlejohns, Peter

AU - Loke, Yoon

AU - Madhock, Rajan

AU - McPherson, Kim

AU - Rothwell, Peter

AU - Summerskill, Bill

AU - Taggart, David

AU - Tekkis, Parris

AU - Thompson, Matthew

AU - Treasure, Tom

AU - Trohler, Ulrich

AU - Vandenbroucke, Jan

AU - Balliol Collaboration

PY - 2009/9/26

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N2 - Research on surgical interventions is associated with several methodological and practical challenges of which few, if any, apply only to surgery. However, surgical evaluation is especially demanding because many of these challenges coincide. In this report, the second of three on surgical innovation and evaluation, we discuss obstacles related to the study design of randomised controlled trials and non-randomised studies assessing surgical interventions. We also describe the issues related to the nature of surgical procedures-for example, their complexity, surgeon-related factors, and the range of outcomes. Although difficult, surgical evaluation is achievable and necessary. Solutions tailored to surgical research and a framework for generating evidence on which to base surgical practice are essential.

AB - Research on surgical interventions is associated with several methodological and practical challenges of which few, if any, apply only to surgery. However, surgical evaluation is especially demanding because many of these challenges coincide. In this report, the second of three on surgical innovation and evaluation, we discuss obstacles related to the study design of randomised controlled trials and non-randomised studies assessing surgical interventions. We also describe the issues related to the nature of surgical procedures-for example, their complexity, surgeon-related factors, and the range of outcomes. Although difficult, surgical evaluation is achievable and necessary. Solutions tailored to surgical research and a framework for generating evidence on which to base surgical practice are essential.

U2 - 10.1016/S0140-6736(09)61086-2

DO - 10.1016/S0140-6736(09)61086-2

M3 - Article

C2 - 19782875

SN - 1474-547X

VL - 374

SP - 1097

EP - 1104

JO - Lancet

JF - Lancet

IS - 9695

ER -

Challenges in evaluating surgical innovation

Abstract

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