CFD-DNS simulation of irregular-shaped particle dissolution

Hui Cao*, Xiaodong Jia, Yongliang Li, Carlos Amador, Yulong Ding

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

A coupled approach between the conventional computational fluid dynamics platform COMSOL and an in-house-developed direct numerical simulation code DigiDiss is presented to study the dissolution kinetics of an irregular-shaped particle in a stirred cuvette. The complex flow dynamics from COMSOL were imported into DigiDiss as an initial flow condition. A digitised 3D particle structure scanned and reconstructed by X-ray micro-tomography was used in the dissolution simulation. A quantitative assessment of the simulation results was made using as a reference experimental data and a theoretical calculation based on the shrinking spherical model with different flow velocity profiles near the particle. The comprehensive agreement demonstrates the coherence of the simulation method in reproducing the experimental behaviour and is seen as a step closer towards developing a computer software design aide to help with formulation development.

Original languageEnglish
Pages (from-to)144-155
Number of pages12
JournalParticuology
Volume50
DOIs
Publication statusPublished - Jun 2020

Keywords

  • Computational fluid dynamics
  • Direct numerical simulation
  • Single particle dissolution
  • X-ray micro-tomography

ASJC Scopus subject areas

  • Chemical Engineering(all)
  • Materials Science(all)

Fingerprint

Dive into the research topics of 'CFD-DNS simulation of irregular-shaped particle dissolution'. Together they form a unique fingerprint.

Cite this