Cerebral pressure-flow relationship in lowlanders and natives at high altitude

Research output: Contribution to journalArticle


  • Jonathan D. Smirl
  • Nia C. S. Lewis
  • Gregory R. duManior
  • Kurt J. Smith
  • Akke Bakker
  • Aperna S. Basnyat
  • Philip N. Ainslie

Colleges, School and Institutes

External organisations

  • University of British Columbia Okanagan
  • Okanagan College
  • University of Twente
  • Good Samaritan Hospital


We investigated if dynamic cerebral pressure-flow relationships in lowlanders are altered at high altitude (HA), differ in HA natives and after return to sea level (SL). Lowlanders were tested at SL (n=16), arrival to 5,050 m, after 2-week acclimatization (with and without end-tidal PO2 normalization), and upon SL return. High-altitude natives (n=16) were tested at 5,050 m. Testing sessions involved resting spontaneous and driven (squat-stand maneuvers at very low (VLF, 0.05 Hz) and low (LF, 0.10 Hz) frequencies) measures to maximize blood pressure (BP) variability and improve assessment of the pressure-flow relationship using transfer function analysis (TFA). Blood flow velocity was assessed in the middle (MCAv) and posterior (PCAv) cerebral arteries. Spontaneous VLF and LF phases were reduced and coherence was elevated with acclimatization to HA (P


Original languageEnglish
Pages (from-to)248-57
Number of pages10
JournalJournal of Cerebral Blood Flow and Metabolism
Issue number2
Early online date30 Oct 2013
Publication statusPublished - 1 Feb 2014