Cerebellar transcranial magnetic stimulation : the role of coil geometry and tissue depth

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Cerebellar transcranial magnetic stimulation : the role of coil geometry and tissue depth. / Hardwick, Robert; Lesage, E.; Miall, R.C.

In: Brain stimulation, Vol. 7, No. 5, 09.2014, p. 643–649.

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@article{139158432f4a40b893195798937d72e0,
title = "Cerebellar transcranial magnetic stimulation : the role of coil geometry and tissue depth",
abstract = "Background: While transcranial magnetic stimulation (TMS) coil geometry has important effects on the evoked magnetic field, no study has systematically examined how different coil designs affect the effectiveness of cerebellar stimulation. Hypothesis: The depth of the cerebellar targets will limit efficiency. Angled coils designed to stimulate deeper tissue are more effective in eliciting cerebellar stimulation. Methods: Experiment 1 examined basic input-output properties of the figure-of-eight, batwing and double-cone coils, assessed with stimulation of motor cortex. Experiment 2 assessed the ability of each coil to activate cerebellum, using cerebellar-brain inhibition (CBI). Experiment 3 mapped distances from the scalp to cerebellar and motor cortical targets in a sample of 100 subjects' structural magnetic resonance images. Results: Experiment 1 showed batwing and double-cone coils have significantly lower resting motor thresholds, and recruitment curves with steeper slopes than the figure-of-eight coil. Experiment 2 showed the double-cone coil was the most efficient for eliciting CBI. The batwing coil induced CBI only at higher stimulus intensities. The figure-of-eight coil did not elicit reliable CBI. Experiment 3 confirmed that cerebellar tissue is significantly deeper than primary motor cortex tissue, and we provide a map of scalp-to-target distances. Conclusions: The double-cone and batwing coils designed to stimulate deeper tissue can effectively stimulate cerebellar targets. The double-cone coil was found to be most effective. The depth map provides a guide to the accessible regions of the cerebellar volume. These results can guide coil selection and stimulation parameters when designing cerebellar TMS studies.",
keywords = "Batwing coil, Cerebellar brain inhibition, Cerebello brain inhibition, Cerebellum, Deep TMS, Double cone coil, Figure-of-eight coil, TMS, TMS coil geometry",
author = "Robert Hardwick and E. Lesage and R.C. Miall",
year = "2014",
month = sep,
doi = "10.1016/j.brs.2014.04.009",
language = "English",
volume = "7",
pages = "643–649",
journal = "Brain stimulation",
issn = "1935-861X",
publisher = "Elsevier",
number = "5",

}

RIS

TY - JOUR

T1 - Cerebellar transcranial magnetic stimulation : the role of coil geometry and tissue depth

AU - Hardwick, Robert

AU - Lesage, E.

AU - Miall, R.C.

PY - 2014/9

Y1 - 2014/9

N2 - Background: While transcranial magnetic stimulation (TMS) coil geometry has important effects on the evoked magnetic field, no study has systematically examined how different coil designs affect the effectiveness of cerebellar stimulation. Hypothesis: The depth of the cerebellar targets will limit efficiency. Angled coils designed to stimulate deeper tissue are more effective in eliciting cerebellar stimulation. Methods: Experiment 1 examined basic input-output properties of the figure-of-eight, batwing and double-cone coils, assessed with stimulation of motor cortex. Experiment 2 assessed the ability of each coil to activate cerebellum, using cerebellar-brain inhibition (CBI). Experiment 3 mapped distances from the scalp to cerebellar and motor cortical targets in a sample of 100 subjects' structural magnetic resonance images. Results: Experiment 1 showed batwing and double-cone coils have significantly lower resting motor thresholds, and recruitment curves with steeper slopes than the figure-of-eight coil. Experiment 2 showed the double-cone coil was the most efficient for eliciting CBI. The batwing coil induced CBI only at higher stimulus intensities. The figure-of-eight coil did not elicit reliable CBI. Experiment 3 confirmed that cerebellar tissue is significantly deeper than primary motor cortex tissue, and we provide a map of scalp-to-target distances. Conclusions: The double-cone and batwing coils designed to stimulate deeper tissue can effectively stimulate cerebellar targets. The double-cone coil was found to be most effective. The depth map provides a guide to the accessible regions of the cerebellar volume. These results can guide coil selection and stimulation parameters when designing cerebellar TMS studies.

AB - Background: While transcranial magnetic stimulation (TMS) coil geometry has important effects on the evoked magnetic field, no study has systematically examined how different coil designs affect the effectiveness of cerebellar stimulation. Hypothesis: The depth of the cerebellar targets will limit efficiency. Angled coils designed to stimulate deeper tissue are more effective in eliciting cerebellar stimulation. Methods: Experiment 1 examined basic input-output properties of the figure-of-eight, batwing and double-cone coils, assessed with stimulation of motor cortex. Experiment 2 assessed the ability of each coil to activate cerebellum, using cerebellar-brain inhibition (CBI). Experiment 3 mapped distances from the scalp to cerebellar and motor cortical targets in a sample of 100 subjects' structural magnetic resonance images. Results: Experiment 1 showed batwing and double-cone coils have significantly lower resting motor thresholds, and recruitment curves with steeper slopes than the figure-of-eight coil. Experiment 2 showed the double-cone coil was the most efficient for eliciting CBI. The batwing coil induced CBI only at higher stimulus intensities. The figure-of-eight coil did not elicit reliable CBI. Experiment 3 confirmed that cerebellar tissue is significantly deeper than primary motor cortex tissue, and we provide a map of scalp-to-target distances. Conclusions: The double-cone and batwing coils designed to stimulate deeper tissue can effectively stimulate cerebellar targets. The double-cone coil was found to be most effective. The depth map provides a guide to the accessible regions of the cerebellar volume. These results can guide coil selection and stimulation parameters when designing cerebellar TMS studies.

KW - Batwing coil

KW - Cerebellar brain inhibition

KW - Cerebello brain inhibition

KW - Cerebellum

KW - Deep TMS

KW - Double cone coil

KW - Figure-of-eight coil

KW - TMS

KW - TMS coil geometry

UR - http://www.scopus.com/inward/record.url?eid=2-s2.0-84901736489&partnerID=8YFLogxK

U2 - 10.1016/j.brs.2014.04.009

DO - 10.1016/j.brs.2014.04.009

M3 - Article

C2 - 24924734

VL - 7

SP - 643

EP - 649

JO - Brain stimulation

JF - Brain stimulation

SN - 1935-861X

IS - 5

ER -