Cell cycle and cell size dependence of susceptibility of hydrodynamic forces

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Colleges, School and Institutes

Abstract

Exposure of animal cells to intense hydrodynamic forces exerted in turbulent capillary flow, and by controlled agitation and aeration, resulted in preferential destruction of S and G2 cells and the extent of destruction of these cells was dependent upon the intensity of the action. The loss of these cells was possibly due to their larger size. However, the appearance of large numbers of membrane-bound vesicular structures similar to apoptotic bodies as well as cells with low DNA stainability (in a sub-G1 peak) suggested that the action of adverse hydrodynamic forces on these large cells may at least in part be to induce an apoptotic response.

Details

Original languageEnglish
Pages (from-to)88-92
Number of pages5
JournalBiotechnology and Bioengineering
Volume46
Issue number1
Publication statusPublished - 5 Apr 1995

Keywords

  • Apoptosis, Cell Culture, Cell cycle, Hydrodynamic forces

ASJC Scopus subject areas