CD8+ T cell immunity to Epstein-Barr virus and Kaposi's sarcoma-associated herpes virus.

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Gammaherpesviruses are agents which have evolved to persist within the lymphoid system and many have oncogenic potential; studying gammaherpesvirus infections therefore has the potential to reveal much about the workings of the immune system and the control over viral oncogenesis. The lymphocryptovirus Epstein-Barr virus (EBV) and the rhadinovirus Kaposi's sarcoma-associated herpesvirus (KSHV, also known as human herpesvirus 8) are the two human gammaherpesviruses. Analysis of the T cell response to EBV has guided understanding of immunity to infection and disease caused by this virus, as well as directed the development of vaccination and therapeutic interventions in EBV-associated disease. Less is known about the T cell response to KSHV and its exact role in controlling virus infection and disease. Here we discuss the CD8+ T cell response to these two gammaherpesviruses.


Original languageEnglish
Pages (from-to)416-22
Number of pages7
JournalSeminars in Cancer Biology
Issue number6
Publication statusPublished - 1 Dec 2008


  • Epstein-Barr virus, Cellular immunology, Kaposi's sarcoma-associated herpesvirus, CD8 T cell