TY - JOUR
T1 - CD4+ T cell responses to Epstein-Barr virus nuclear antigen EBNA1 in Chinese populations are highly focused on novel C-terminal domain epitopes
AU - Tsang, Chi
AU - Lin, X
AU - Gudgeon, Nancy
AU - Taylor, Graham
AU - Jia, Hui
AU - Hui, P
AU - Chan, ATC
AU - Lin, CK
AU - Rickinson, Alan
PY - 2006/8/15
Y1 - 2006/8/15
N2 - Epstein-Barr virus nuclear antigen EBNA1, the one viral protein uniformly expressed in nasopharyngeal carcinoma (NPC), represents a prime target for T-cell-based immunotherapy. However, little is known about the EBNA1 epitopes, particularly CD4 epitopes, presented by HLA alleles in Chinese people, the group at highest risk for NPC. We analyzed the CD4\(^+\) T-cell responses to EBNA1 in 78 healthy Chinese donors and found marked focusing on a small number of epitopes in the EBNA1 C-terminal region, including a DP5- restricted epitope that was recognized by almost half of the donors tested and elicited responses able to recognize EBNA1-expressing, DP5-positive target cells.
AB - Epstein-Barr virus nuclear antigen EBNA1, the one viral protein uniformly expressed in nasopharyngeal carcinoma (NPC), represents a prime target for T-cell-based immunotherapy. However, little is known about the EBNA1 epitopes, particularly CD4 epitopes, presented by HLA alleles in Chinese people, the group at highest risk for NPC. We analyzed the CD4\(^+\) T-cell responses to EBNA1 in 78 healthy Chinese donors and found marked focusing on a small number of epitopes in the EBNA1 C-terminal region, including a DP5- restricted epitope that was recognized by almost half of the donors tested and elicited responses able to recognize EBNA1-expressing, DP5-positive target cells.
UR - http://www.scopus.com/inward/record.url?scp=33746808985&partnerID=8YFLogxK
U2 - 10.1128/JVI.00400-06
DO - 10.1128/JVI.00400-06
M3 - Article
SN - 1098-5514
VL - 80
SP - 8263
EP - 8266
JO - Journal of virology
JF - Journal of virology
ER -
