CD4+ CD28 null T cells in coronary artery disease: when helpers become killers

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CD4+ CD28 null T cells in coronary artery disease : when helpers become killers. / Dumitriu, Ingrid; Araguás, Ernesto Trallero; Baboonian, Christina; Kaski, Juan Carlos.

In: Cardiovascular Research, Vol. 81, No. 1, 01.01.2009, p. 11-9.

Research output: Contribution to journalReview articlepeer-review

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Dumitriu, Ingrid ; Araguás, Ernesto Trallero ; Baboonian, Christina ; Kaski, Juan Carlos. / CD4+ CD28 null T cells in coronary artery disease : when helpers become killers. In: Cardiovascular Research. 2009 ; Vol. 81, No. 1. pp. 11-9.

Bibtex

@article{ed4447d8b8b649e8992ec18d009efa62,
title = "CD4+ CD28 null T cells in coronary artery disease: when helpers become killers",
abstract = "The crucial role of T cells in atherosclerosis and coronary artery disease (CAD) has been highlighted by recent observations. Helper CD4(+) T cells can both aggravate or attenuate the atherogenic process and the development of CAD. CD4(+)CD28(null) T cells are an unusual subset of helper cells which expand and have deleterious effects in CAD. In this review, we discuss the current issues on the generation of CD4(+)CD28(null) T cells and focus on their phenotypic and functional characteristics relevant to the development of cardiovascular events. The possible effects of the present day therapies for CAD on the CD4(+)CD28(null) T cells are also explored. Targeting the CD4(+)CD28(null) T cell subset in CAD could provide novel therapeutic strategies to prevent acute life-threatening coronary events.",
keywords = "Animals, Autoimmune Diseases/pathology, CD28 Antigens/genetics, Coronary Artery Disease/drug therapy, Coronary Vessels/pathology, Disease Models, Animal, Humans, T-Lymphocytes, Helper-Inducer/immunology, Thrombosis/pathology",
author = "Ingrid Dumitriu and Aragu{\'a}s, {Ernesto Trallero} and Christina Baboonian and Kaski, {Juan Carlos}",
year = "2009",
month = jan,
day = "1",
doi = "10.1093/cvr/cvn248",
language = "English",
volume = "81",
pages = "11--9",
journal = "Cardiovascular Research",
issn = "0008-6363",
publisher = "Oxford University Press",
number = "1",

}

RIS

TY - JOUR

T1 - CD4+ CD28 null T cells in coronary artery disease

T2 - when helpers become killers

AU - Dumitriu, Ingrid

AU - Araguás, Ernesto Trallero

AU - Baboonian, Christina

AU - Kaski, Juan Carlos

PY - 2009/1/1

Y1 - 2009/1/1

N2 - The crucial role of T cells in atherosclerosis and coronary artery disease (CAD) has been highlighted by recent observations. Helper CD4(+) T cells can both aggravate or attenuate the atherogenic process and the development of CAD. CD4(+)CD28(null) T cells are an unusual subset of helper cells which expand and have deleterious effects in CAD. In this review, we discuss the current issues on the generation of CD4(+)CD28(null) T cells and focus on their phenotypic and functional characteristics relevant to the development of cardiovascular events. The possible effects of the present day therapies for CAD on the CD4(+)CD28(null) T cells are also explored. Targeting the CD4(+)CD28(null) T cell subset in CAD could provide novel therapeutic strategies to prevent acute life-threatening coronary events.

AB - The crucial role of T cells in atherosclerosis and coronary artery disease (CAD) has been highlighted by recent observations. Helper CD4(+) T cells can both aggravate or attenuate the atherogenic process and the development of CAD. CD4(+)CD28(null) T cells are an unusual subset of helper cells which expand and have deleterious effects in CAD. In this review, we discuss the current issues on the generation of CD4(+)CD28(null) T cells and focus on their phenotypic and functional characteristics relevant to the development of cardiovascular events. The possible effects of the present day therapies for CAD on the CD4(+)CD28(null) T cells are also explored. Targeting the CD4(+)CD28(null) T cell subset in CAD could provide novel therapeutic strategies to prevent acute life-threatening coronary events.

KW - Animals

KW - Autoimmune Diseases/pathology

KW - CD28 Antigens/genetics

KW - Coronary Artery Disease/drug therapy

KW - Coronary Vessels/pathology

KW - Disease Models, Animal

KW - Humans

KW - T-Lymphocytes, Helper-Inducer/immunology

KW - Thrombosis/pathology

U2 - 10.1093/cvr/cvn248

DO - 10.1093/cvr/cvn248

M3 - Review article

C2 - 18818214

VL - 81

SP - 11

EP - 19

JO - Cardiovascular Research

JF - Cardiovascular Research

SN - 0008-6363

IS - 1

ER -