CD248/Endosialin is dynamically expressed on a subset of stromal cells during lymphoid tissue development, splenic remodeling and repair

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@article{00faf7478f3342abb7b40860eab41375,
title = "CD248/Endosialin is dynamically expressed on a subset of stromal cells during lymphoid tissue development, splenic remodeling and repair",
abstract = "Studies of stromal cell populations in lymphoid tissue (LT) have been hampered by a lack of selective markers. Here, we show that CD248 (Endosialin/TEM1) is a stromal marker that is differentially expressed on fibroblasts and pericytes in the thymus, lymph node and spleen. Expression is high during LT development but largely disappears in the adult. CD248 is re-expressed in a Salmonella-induced model of splenic enlargement; peak expression corresponding to the peak of splenic enlargement. These results suggest that CD248 expression helps define a subset of LT stromal cells which play a role in remodelling during tissue development, infection and repair.",
keywords = "tissue repair, stromal cells, CD248, Salmonella",
author = "Sian Lax and Tiezheng Hou and Eric Jenkinson and Michael Salmon and Robert Macfadyen and CM Isacke and Graham Anderson and Adam Cunningham and Christopher Buckley",
year = "2007",
month = jul,
day = "24",
doi = "10.1016/j.febslet.2007.06.063",
language = "English",
volume = "581",
pages = "3550--3556",
journal = "FEBS Letters",
issn = "0014-5793",
publisher = "Elsevier",
number = "18",

}

RIS

TY - JOUR

T1 - CD248/Endosialin is dynamically expressed on a subset of stromal cells during lymphoid tissue development, splenic remodeling and repair

AU - Lax, Sian

AU - Hou, Tiezheng

AU - Jenkinson, Eric

AU - Salmon, Michael

AU - Macfadyen, Robert

AU - Isacke, CM

AU - Anderson, Graham

AU - Cunningham, Adam

AU - Buckley, Christopher

PY - 2007/7/24

Y1 - 2007/7/24

N2 - Studies of stromal cell populations in lymphoid tissue (LT) have been hampered by a lack of selective markers. Here, we show that CD248 (Endosialin/TEM1) is a stromal marker that is differentially expressed on fibroblasts and pericytes in the thymus, lymph node and spleen. Expression is high during LT development but largely disappears in the adult. CD248 is re-expressed in a Salmonella-induced model of splenic enlargement; peak expression corresponding to the peak of splenic enlargement. These results suggest that CD248 expression helps define a subset of LT stromal cells which play a role in remodelling during tissue development, infection and repair.

AB - Studies of stromal cell populations in lymphoid tissue (LT) have been hampered by a lack of selective markers. Here, we show that CD248 (Endosialin/TEM1) is a stromal marker that is differentially expressed on fibroblasts and pericytes in the thymus, lymph node and spleen. Expression is high during LT development but largely disappears in the adult. CD248 is re-expressed in a Salmonella-induced model of splenic enlargement; peak expression corresponding to the peak of splenic enlargement. These results suggest that CD248 expression helps define a subset of LT stromal cells which play a role in remodelling during tissue development, infection and repair.

KW - tissue repair

KW - stromal cells

KW - CD248

KW - Salmonella

U2 - 10.1016/j.febslet.2007.06.063

DO - 10.1016/j.febslet.2007.06.063

M3 - Article

C2 - 17628549

VL - 581

SP - 3550

EP - 3556

JO - FEBS Letters

JF - FEBS Letters

SN - 0014-5793

IS - 18

ER -