CD248 expression on mesenchymal stromal cells is required for post-natal and infection-dependent thymus remodelling and regeneration
Research output: Contribution to journal › Article › peer-review
Authors
Colleges, School and Institutes
Abstract
The role of mesenchymal stromal cells (MSCs) in regulating immune responses in the thymus is currently unclear. Here we report the existence and role of a MSC population in the thymus that expresses the pericyte and MSC marker CD248 (endosialin). We show using a CD248-deficient mouse model, that CD248 expression on these cells is required for full post-natal thymus development and regeneration post-Salmonella infection. In CD248−/− mice the thymus is hypocellular and regeneration is poorer, with significant loss of all thymocyte populations. This identifies the requirement of CD248 to maintain optimal thymic cellularity post-partum and infection.
Details
Original language | English |
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Pages (from-to) | 187-190 |
Number of pages | 4 |
Journal | FEBS Open Bio |
Volume | 2 |
Early online date | 20 Jul 2012 |
Publication status | Published - 2012 |
Keywords
- CD248, Endosialin, MSC, Thymus